Pharmacogenomics Flashcards
alleles, CI, testing
1
Q
abacavir should not be used in
A
HLA-B*5701 (+)
2
Q
allopurinol should not be used in
A
HLA-B*5801 (+)
3
Q
if a patient is HLA-B*1502 (+), they should not receive
A
oxcarbazepine
carbamazepine
phenytoin
fosphenytoin
4
Q
clopidogrel should not be used in
A
2C19 polymoprhisms
5
Q
codeine should not be used in
A
2D6 polymorphisms
6
Q
warfarin should not be used in
A
2C9, 1A2, VKORCI polymorphisms
7
Q
patients must be _______ (+) to use trastuzumab
A
HER2+
brand is HERceptin!
8
Q
cetuximab should not be used in
A
KRAS mutation
9
Q
capecitabine (Xeloda) and FU should not be used in
A
DPD deficency
10
Q
genomic testing is required or high rec for
A
trastuzumab and other HER2 - i
azathioprine
cetuximab and other EGFR
carbamazepine
