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NAPLEX Prep > GERD & PUD > Flashcards

GERD & PUD Flashcards

1
Q

What drugs worsen GERD sx

A

ASA/NSAIDs
fish oils
bisphosphonates
iron supplements
NRT
steroids
TTC
dabigatran

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2
Q

patient who experiences GERD sx about once a week.
tx recommendation?

A

<2x/week so can do OTC antacids or H2RA

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3
Q

what are the criteria for a patient to receive 8 week PPI instead of OTC antacids or H2RA

A

2+ incidences of HB a week

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4
Q

Ca carbonate brand

A

Tums

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5
Q

Ca carbonate + mag hydroxide

A

Mylanta

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6
Q

mag hydroxide brand

A

MOM

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7
Q

ca carbonate + simethicone

A

Maalox

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8
Q

Al + mag hydroxide + simethicone

A

Mylanta max strength

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9
Q

what are the components of Alka Seltzer

A

ASA
sodium bicarb
citric acid

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10
Q

Al and Ca products are CI in _____. why?

A

CI in CrCl <30 due to renal deposits

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11
Q

what is the preferred treatment for acid reflux in pregnancy

A

ca carbonate (tums)

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12
Q

how long do antacids typically last

A

30-60 min

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13
Q

how do antacids work

A

produce salt and water to increase gastric pH

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14
Q

famotidine
brand name
dosing

A

Pepcid
OTC: 10-20mg PO QD-BID PRN
Rx: 20mg PO BID
de dose if CrCl <60 2/2 ECG changes with renal dysfunction

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15
Q

famotidine (Pepcid) comes in combinations with

A

mag hydroxide (Pepcid complete)
ibuprofen (Duexis)

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16
Q

when should famotidine be taken

A

30-60 min before a meal

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17
Q

adverse effects of famotidine

A

ECG changes in renal dysfunction
psych SE
B12 deficiency
HA

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18
Q

H2RAs are reversible or irreversible?

A

reversible

19
Q

cimetidine dosing

A

OTC: 200mg 1-2x/day PRN
Rx: 400mg PO Q6H

20
Q

SE of all H2RAs

A

HA
B12 deficiency

21
Q

what H2RA was pulled of the market in April of 2020

A

ranitidine

22
Q

dexlansoprazole
brand
OTC, Rx or both?
dosing

A

Dexilant
Rx only
30-60mg PO QD without regard to meals

23
Q

pantoprazole
brand
OTC, Rx or both?
dosing

A

Protonix
Rx only
40mg PO QD

24
Q

what PPIs are available IV

A

pantoprazole
esomeprazole

25
Q

adverse effects of pantoprazole IV

A

thrombophlebitis
SJS/TEN

26
Q

omeprazole
brand
OTC, Rx or both?
dosing

A

Prilosec
Rx and OTC
OTC: 20mg PO QD
RX: 20-40mg PO QD

27
Q

pantoprazole and dexlansoprazole can be taken

A

without regard to meals

28
Q

omeprazole comes in which dosage forms SATA

A. IV
B. cap
C. tab
D. powder for suspension
E. solution
F. ODT

A

B. cap
C. tab
D. powder for suspension

F. ODT

29
Q

esomeprazole
brand
OTC, Rx or both?
dosing

A

Nexium
OTC and Rx
OTC: 20mg PO QD
Rx: 20-40mg PO QD

30
Q

lansoprazole
brand
OTC, Rx or both?
dosing

A

Prevacid
OTC and Rx
OTC: 15mg PO QD
Rx: 15-30mg PO QD

31
Q

which PPIs come in a packet for suspension

A

opemrazole (Prilosec)
esomeprazole (Nexium)
pantoprazole (Protonix)

32
Q

which PPIs come in ODT form

A

omeprazole (Prilosec)
lansoprazole (Prevacid)

33
Q

warnings for all PPIs

A

c. diff diarrhea
B2 deficiency when used 2+ years
OP related fractures if high dose or 1+ years
hypomagnesemia
AIN
SJS/TEN
DO NOT USE X>8 WEEKS IN ELDERLY

34
Q

DDI between esomeprazole and omeprazole with plavix

A

omeprazole and esomeprazole inhibit 2C19 which activates plavix and they therefore decrease plavix efficacy

35
Q

what drugs need an acidic gut and therefore interact with antacids, H2RAs and PPIs

A

rilpivirine (NNRTI), atazanavir (PI)
-azoles
cefpodoxime and cefuroxime (po cephalos)
iron products
mesalamine
rsendronate DR
TK-is (-nibs)

36
Q

what drugs bind antacids

A

INSTIs
levothyroxine
bisphosphonates
isoniazid
MMF
FQs
sotalol
TTCs
steroids

37
Q

first line treatment for h, pylori PUD

A

BSS quad therapy
BSS 300mg PO QID +
metronidazole 250-500mg PO QID +
tetracycline 500mg QID +
PPI BID
all x14 days

38
Q

counseling points for BSS Quad therapy for h pylori

A

no pregnancy
no alcohol
not for <8 yo

39
Q

when are clarithromycin-containing h pylori regimens appropriate

A

if resistance is <15% AND the patient has never ever received a macrolide in their life for any reason

40
Q

risk factors for NSAID-induced ulcers

A

> 60 yo
high dose NSAIDs
use with ASA
use with anticoagulants, steroids, SSRI, SNRI
use of >1 NSAID
hx of any PUD

41
Q

NSAID-induced PUD tx

A

PPI x8 weeks

42
Q

alternatives to PPI treatment for NSAID-induced PUD

A

hgh dose H2RA or sucralfate

43
Q

sucralfate dosing

A

1g PO QID before meals

NAPLEX Prep (57 decks)

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