Vulvar and Vaginal Neoplasms Flashcards
Vulvar neoplasms are usually what type?
Squamous Cell Carcinomas
When do Vulvar neoplasms usually occur?
Post-menopause
– > 65 yo
What is the most frequently reported symptom of Vulvar Neoplasms?
Long history of chronic vulvar pruritus
What is the most frequently reported symptom of Vulvar neoplasms?
Long history of chronic vulvar pruritus
VIN
Vulvar Intraepithelial neoplasia — precursor lesion
Classic VIN
Associated with HPV 16, smoking and immunocompromised
Differentiated VIN
Associated with vulvar dermatologic conditions
What is the treatment for VIN III?
Local surgical excision – 5 mm
What is the treatment for small VIN III lesions?
Laser therapy
- take biopsies too
Paget’s disease is also a preinvasive condition. What does it look like?
Red with white plaque lesions, itching and tenderness
Squamous Cell Vulvar Carcinoma is usually where and whats the symptom?
Labia majora
= Itch
What are 2 treatment options for Squamous Cell Vulvar Carcinoma?
- Radical vulvectomy and regional lymphadenectomy
- Tumor excision, inguinal node dissection, chemo/radiation
Verrucous Carcinoma can also occur on the vulva. What is it?
Squamous Cell Carcinoma variant
How does Verrucous Carcinoma look on the vulva?
Cauliflower lesion
What treatment is contraindicated with Verrucous Carcinomas and why?
Radiation
-> anaplastic transformation
Bartholin’s gland carcinoma can also occur. Symptom?
Painless mass
Will a patient with a Bartholin’s gland carcinoma have a history of Bartholin gland issues?
NO
What is the treatment for Bartholin’s Gland Carcinoma?
Radical vulvectomy, bilateral lymphadenectomy, radiation
Is recurrence common with Bartholin’s Gland Carcinoma?
Yes
VAIN
Vaginal Intraepithelial Neoplasia – precursor lesion
What is VAIN associated with?
HPV
Symptom of VAIN?
Asymptomatic
Vaginal Carcinoma is usually what type?
Squamous Cell Carcinoma
What are the symptoms of Vaginal Squamous Cell Carcinoma?
Abnormal vaginal discharge/bleeding and hematuria
