Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ENRP > Ante/Perinatal Pharmacology cont. > Flashcards

Ante/Perinatal Pharmacology cont. Flashcards

1
Q

Uterotonics are used for uterine stimulation. What 3 things can they do?

A
  1. Cervical ripening
  2. Induction of contractions
  3. Control postpartum bleed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does cervical ripening involve?

A

Collagen and glycosaminoglycans broken down

=> cervix is thinned and dilated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is Misoprostol?

A

PGE1 Analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How should Misoprostol be stored? How long does it take for onset?

A

Stable at room temperature

– 30 minutes for onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are some maternal adverse effects seen with Misoprostol?

A

N/V, pain, chills, shivering

- Abnormal uterine contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a fetal adverse effect that can occur with Misoprostol in response to it causing abnormal uterine contractions?

A

Hypoxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Prostaglandin E1 Analog that can terminate pregnancy if within 77 days

A

Misoprostol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is Dinoprostone?

A

PGE2 Analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How should Dinoprostone be stored? Time to onset?

A

Needs to be refrigerated

– onset is within minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When Dinoprostone is given for abortions, what adverse effect can occur?

A

Fever that is unresponsive to NSAIDs and lasts for about 6 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is a contraindication for giving Misoprostol or Dinoprostone?

A

Prior C-section

– can rupture uterine scar!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a possible fetal adverse effect that can occur with Dinoprostone?

A

Hypoxia

– due to abnormal uterine contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drug can cause a fever that is unresponsive to NSAIDs for 6 hours?

A

Dinoprostone

– seen with abortion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is Carboprost?

A

Prostaglandin F2alpha analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is Carboprost and how is it given?

A

Prostaglandin F2alpha Analog

– IM injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are 2 contraindications for giving Carboprost?

A

PID

Active organ disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is Oxytocin?

A

Posterior pituitary hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are 2 contraindications for use of Oxytocin?

A

If cervix is not ripe

If fetal lungs are not mature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is a possible maternal adverse effect that can occur with Oxytocin?

A 
Water intoxication
(hyponatremia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

If water intoxication occurs, what drug was given to control a postpartum bleed?

A

Oxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is a contraindication for Ergot Alkaloids?

A

HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What drugs are constrictors from rye fungus and thus constrict arterioles/veins?

A

Ergot alkaloids

23
Q

What is a possible adverse effect of Ergot Alkaloids that are used to control a postpartum bleed?

A

St. Anthony’s fire

= mania, psychosis, dry gangrene

24
Q

Mania, psychosis and dry gangrene is seen with what drug?

A

Ergot alkaloids

– St. Anthony’s Fire

25
Q

What is a common reason that Tocolytics are used?

A

Need time for corticosteroids to trigger surfactant production and brain maturation

26
Q

What is a risk factor for RDS and what is it?

A

Preterm birth usually before 32 weeks

– deficient surfactant production from type 2 pneumocytes

27
Q

What are Corticosteroids used for?

A

Promote lung maturation and surfactant production

28
Q

What are corticosteroids used for?

A

Promote lung maturation and surfactant production

29
Q

When are corticosteroids indicated?

A

Between 24-36 weeks with any sign of:

  • preterm labor, hemorrhage, membrane rupture
  • preeclampsia/HELLP c-section conditions
30
Q

How is Betamethasone given?

A

2 doses via IM injection at 24 hour intervals

31
Q

How is Dexamethasone given?

A

4 doses via IM injection at 12 hour intervals

32
Q

With the treatment of RDS, what is done first?

A

CPAP

33
Q

With the treatment of RDS, after CPAP, the FiO2 is measured. If it is greater than 0.4, what is done?

A

Surfactant therapy and intubate

34
Q

With the treatment of RDS, after CPAP, FiO2 is measured. If it is less than 0.4, what is done?

A

CPAP and ABG

35
Q

If an ABG is obtained on a neonate with RDS, with what pH level will you consider surfactant therapy and intubation?

A

< 7.2

36
Q

What can Magnesium Sulfate do?

A

Neuroprotection of fetus

– decreases risk of cerebral palsy

37
Q

MOA for Magnesium sulfate?

A

Unknown – competes with calcium

38
Q

Terbutaline is a? What does it do molecularly?

A

Beta2 agonist

– increases cAMP, hyperpolarization and dephosphorylation

39
Q

What are contraindications for Terbutaline and why?

A

Cardiac/Thyroid disease and DM

–> Hyperinsulinemia and heart events

40
Q

What is Nifedipine?

A

Calcium Channel Blocker

41
Q

MOA for Indomethacin?

A

Blocks synthesis of prostaglandin F2alpha

42
Q

What drug blocks synthesis fo PGF2alpha?

A

Indomethacin

43
Q

MOA for Atosiban?

A

(-) Oxytocin

44
Q

What drug blocks Oxytocin?

A

Atosiban

45
Q

Tocolytics may be able to delay labor but can they stop it? Other things to know?

A

NO

– Do NOT combine them and treat for less than 72 hours

46
Q

What is Erythromycin used for?

A

Prophylaxis against gonococcal conjunctivitis

47
Q

What is Alprostadil and what does it do?

A

Synthetic PGE1 for parenteral admin

= maintains PDA

48
Q

What is a possible side effect of Alprostadil?

A

Pyrexia

49
Q

What is a possible side effect of Indomethacin and Ibuprofen that are used to close PDA?

A

Decreased kidney function

50
Q

Decreased levels of ____ cause the PDA to close

A

PGE2

51
Q

Alpha 2 agonist used for HTN in pregnancy?

A

Methyldopa

52
Q

Alpha/Beta Blocker used for HTN in pregnancy?

A

Labetalol

53
Q

Arterial vasodilator used for HTN in pregnancy?

A

Hydralazine

54
Q

Arterial and Venous Vasodilator for HTN in pregnancy?

A

Sodium Nitroprusside

ENRP (45 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions