Part 3 Gyn. Infections

Question 1

Presentation of Genital Herpes?

Answer 1

Painful genital sores

Bilateral LAD

Question 2

Presentation of Genital Herpes?

Answer 2

Painful genital sores

Bilateral LAD

Question 3

If the Genital Herpes is RECURRENT, how will it present?

Answer 3

Cluster of vesicles that will rupture and ulcerate

LAD on 1 side

Question 4

Recurrent Genital Herpes is latent where? Is it more severe or less severe than the primary presentation?

Answer 4

Sacral Ganglia

– LESS severe

Question 5

HSV is a lifelong DNA virus. HSV 1 and 2 usually affect what areas?

Answer 5

HSV1 = orofacial
HSV2 = genital

Question 6

If you see “molding, multinucleation, margination” on biopsy, think?

Answer 6

HSV

Question 7

The treatment for Genital Herpes uses what MOA?

Answer 7

(-) DNA synthesis

Question 8

What are 3 treatment options for Genital Herpes that (-) DNA synthesis?

Answer 8

1. Acyclovir
2. Valacyclovir
3. Famciclovir

Question 9

What are 3 treatment options for Genital Herpes that (-) DNA synthesis?

Answer 9

1. Acyclovir
2. Valacyclovir
3. Famciclovir

Question 10

How does Acyclovir Resistance develop?

Answer 10

Decreased production of viral thymidine kinase

=> NO activation of Acyclovir

Question 11

What bacteria causes Syphilis?

Answer 11

Treponema Pallidum

Question 12

What will be seen on stain and biopsy with Treponema Pallidum?

Answer 12

Stain = corkscrew
Biopsy = lymphoplasmacytic infiltrate

Question 13

With Syphilis, what develops 3-6 weeks after sexual contact?

Answer 13

PainLESS Chancre

Question 14

Primary syphilis

Answer 14

PainLESS chancre 6 weeks after sexual contact

Question 15

6 weeks after the painless chancre with primary syphilis, what will present?

Answer 15

Condyloma latum
Macular red rash involves palms and soles
Patchy hair loss

Question 16

Secondary Syphilis

Answer 16

Condyloma Latum
Macular red rash involving palms/soles
Patchy hair loss

Question 17

6-40 years after secondary syphilis, what arises?

Answer 17

Gummatous lesions
Thoracic Aortic Aneurysm
Tabes Dorsalis

Question 18

Tabes Dorsalis affects the posterior columns and dorsal root. What are the symptoms?

Answer 18

Decreased coordination, pain, temperatures sensation

Loss of proprioception

Question 19

What are Argyll Robertson pupils that can be seen with Tertiary Syphilis?

Answer 19

(-) light reflex

(+) accommodation reflex

Question 20

Tertiary Syphilis

Answer 20

Gummatous lesions
Thoracic Aortic Aneurysm
Tabes Dorsalis

Question 21

What are 2 non-treponemal screens that if they come back positive, you should do a specific one?

Answer 21

RPR

VDRL

Question 22

What is a specific treponemal screen for syphilis?

Answer 22

FTA-ABS

Question 23

What is the treatment for primary or secondary Syphilis?

Answer 23

Benzathine Penicillin

– or Doxycycline

Question 24

What is the treatment for Primary or Secondary Syphilis?

Answer 24

Benzathine Penicillin

– Or Doxycycline

Question 25

MOA for the drugs that treat syphilis?

Answer 25

(-) cell wall synthesis

Question 26

What organism usually causes Toxic Shock Syndrome?

Answer 26

Staph. Aureus

Question 27

What are the attributes of Staph. Aureus?

Answer 27

Gram (+) cocci in clusters

- Catalase and Coagulase (+)

Question 28

What are the symptoms of Toxic Shock Syndrome?

Answer 28

Fever
Macular rash that involves the palms and soles
–> desquamation of the skin
Multi-organ involvement and Hypotension

Question 29

What is the action of the TSST-1 Toxin with toxic shock syndrome?

Answer 29

Crosslinks T cells and macrophages

=> releases cytokines

Question 30

Fever, macular rash that involves the palms and soles that then desquamates, hypotension and organ involvement is likely?

Answer 30

Toxic Shock Syndrome