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ENRP > Sex Cord Stromal Ovarian Tumors > Flashcards

Sex Cord Stromal Ovarian Tumors Flashcards

1
Q

What are the 4 types of Sex Cord Stromal Ovarian Tumors?

A

Granulosa cell
Fibroma
Thecoma
Sertoli-leydig

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2
Q

What are the 4 types of Sex Cord Stromal Ovarian Tumors?

A

Granulosa cell
Fibroma
Thecoma
Sertoli-leydig

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3
Q

At what age do Sex Cord Stromal Ovarian tumors arise?

A

ALL ages

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4
Q

What do Granulosa cell tumors release?

A

Estrogen

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5
Q

Adult Granulosa cell tumors occur when?

A

Peri/Post menopausal women

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6
Q

What can occur with Adult Granulosa Cell tumors?

A

Endometrial hyperplasia/carcinoma

– released estrogen

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7
Q

Juvenile Granulosa cell tumors occur around what age?

A

13

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8
Q

What can occur with Juvenile Granulosa cell tumors?

A

Early puberty

– release estrogen

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9
Q

If the Granulosa cell tumors are hormonally active, what color will they be?

A

YELLOW

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10
Q

What type of nuclei do Granulosa cell tumors have?

A

Coffee bean

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11
Q

What bodies are present with Granulosa cell tumors?

A

Cal exner bodies

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12
Q

A yellow tumor that is hormonally active and releasing estrogen

A

Granulosa cell tumor

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13
Q

What stain will be (+) for Granulosa cell tumors and most sex cord stromal tumors?

A

INHIBIN

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14
Q

What stain will be (+) for Granulosa cell tumors?

A

INHIBIN

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15
Q

Fibroma

A

Benign tumor of fibroblasts

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16
Q

What is the Meigs triad?

A

Ascites
Pleural effusion
Ovarian tumor - benign

17
Q

What tumor is the Meigs triad seen with?

A

Fibroma

- ascites, pleural effusion, benign ovarian tumor

18
Q

Thecoma

A

Benign tumor of theca-like cells

19
Q

What can Thecomas release?

A

Estrogen

20
Q

What can Thecomas release?

A

Estrogen

21
Q

What mutation is present with Sertoli-Leydig tumors?

A

Germline DICER1

22
Q

What mutation is present with Sertoli-leydig tumors?

A

Germline DICER1

23
Q

What do Sertoli-leydig tumors release?

A

Testosterone

24
Q

What tumor releases testosterone?

A

Sertoli-leydig

25
Q

What are the symptoms of a Sertoli-leydig tumor?

A

Defeminization

Virilization = male characteristics

26
Q

Defeminization and virilization (male characteristics) is likely what tumor?

A

Sertoli-leydig

27
Q

Reinke crystals are present with what tumor?

A

Sertoli-leydig

ENRP (45 decks)

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