Virology Flashcards
What is viral recombination?
exchange of genes between two chromosomes that have significant base pair homology
What is viral reassortment?
when viruses with segmented genomes exchange segments
What is viral complementation?
when two viruses co-infect a cell and one virus contributes a functional protein to the other
What are the eight live attenuated viruses?
Measles/Mumps/Rubella
Sabin
Smallpox
Yellow fever
varicella
intranasal flu
What are the four killed viruses?
Rabies
Influenza
Polio
hAv
What three nonlinear DNA viruses?
papilloma
polyoma
hepadna
What are the two polyoma viruses?
JC and BK
What is the only dsRNA virus?
Reoviridae
What are the positive stranded RNA viruses?
Retro
Toga
Flavi
Corona
Hepevirus
calcivirus
Picornavirus
What are the two types of nucleic acid that are infective?
dsDNA and (+) ssRNA
The dsDNA of which two viruses is not infective?
HBV and poxvirus
Where do DNA viruses replicate? Except?
nucleus
Pox
Where do all RNA viruses replicate? Two exceptions?
cytoplasm
retro and influenza
What are the eight non-enveloped viruses?
Papilloma
Adeno
parvo
Polymo
Calvi
Picorna
Reo
Hepeviridae
Which virus gains its envelope from the nuclear membrane?
Herpes viruses
Which are the DNA containing non-enveloped?
Papillo
Adeno
Parvo
polymo
Which are the RNA containing non-enveloped?
calvi
picorna
reo
Which are the seven DNA viruses?
Hepadna
Herpes
Adeno
Parvo
Pox
papilloma
polymo
Which DNA virus contains its own DNA dependent RNA polymerase?
Pox
Which virus is HHV5?
CMV
Which virus is HHV6?
roseola
What are two common presenting symptoms of HHV6?
fever for 3-5 days followed by truncal rash
Which virus is one of the most common causes of febrile seizure in kids?
Roseola
Is HBV circular or linear?
circular
Which DNA virus has reverse transcriptase?
HBV
Which virus causes pink eye?
Adeno
What is the most common presenting symptom of parvovirus in adults?
arthritis
Where does the rubella rash start? Where do it go?
head
down
What virus can cause lymphadenopathy in the mother?
Rubella
What two locations can Rubella cause lymphadenopathy?
occipital and posterior auricular
Is dynein retrograde or anterograde?
retro
Cowdry A bodies are indicative of which three viruses?
HSV
CMV
VZV
Which virus can cause swelling of the gums?
Herpes
How is VZV transmitted?
respiratory secretions
Which cell surface receptor does EBV bind?
CD21
Ampicillin can cause a rash in people infected with what virus?
EBV
What CD molecule is contained on the atypical Tcells on peripheral smear during EBV infection?
CD8
Would mononucleosis-like illness caused by CMV be monospot negative or positive?
negative
Kaposis sarcoma is a neoplastic proliferation of what cell type?
endothelial
What two locations can Kaposi’s sarcoma infect other than the skin?
GI and lungs
How is roseola transferred?
Saliva
What are the four symptoms of Dengue Fever?
leukopenia
thrombocytopenia
retro-orbital pain
ecchymoses
Which virus causes Herpangina?
Coxsackie A
What are the five picornavirus?
Polio
Echo
Rhino
Coxsackie
HAV
What is the only hepevirus?
HEV
What is the only calcivirus?
Noro
What are the two retroviruses?
HIV and HTLV
What are the four Paramyxoviridae?
Parainfluenza
Mumps/Measles
RSV
What are the two Filoviruses?
Ebola and Marburg (hemorrhagic fever)
What are the four Bunyaviruses?
California encephalitis
sandfly/rift valley
crimean-congo hemorrhagic fever
Hanta
Which two picarnoviruses are known to cause aseptic meningitis?
Echo
Coxsackie
Where is rhinovirus destroyed?
stomach
Which mosquito transmits Yellow Fever?
Aedes
What are the three symptoms of Yellow Fever infection?
high fever
black vomitus
jaundice
What two viruses are Reoviruses?
Rota and Colti
Is granuloma inguinale painful or painless?
painless
What is the function of hemagglutinin?
promote viral entry
What is the function of neuraminidase?
promote virion release
What are the three main presenting symptoms of rubella in the neonate?
PDA/pulmoary stenosis
Cataracts
deafness
Is measles an ascending or descending rash?
descending
What is used to prevent severe exfoliative dermatitis during a measles infection?
Vitamin A
What are the three inflammatory sites of mumps?
Orchitis
Parotiditis
Meningitis
Where are the two locations of Negri bodies?
Purkinje cells of cerebellum
hippocampal neurons
What receptor does rabies bind?
NAchR
What is a mnemonic to remember that HAV and HEV are fecal-oral?
Vowels hit your Bowels