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Pathology > Viral illness 4 > Flashcards

Viral illness 4 Flashcards

1
Q

Herpes simplex virus 1 is what?

A

Cold sores

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2
Q

Herpes simplex virus 2 is what?

A

Genital herpes

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3
Q

What does herpes simplex virus look like?

A

Large, encapsulated virus with ds DNA genome

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4
Q

Where does HSV remain latent?

A

Nerve cells

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5
Q

What does HSV synthesize while in latent state?

A

Nothing

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6
Q

What will you find if you scrape the lesion of HSV and look at it histologically?

A

Inclusion bearing multinucleate syncytial (giant cells)

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7
Q

Pattern of HSV lesion formation?

A

Bilaterally and ignoring dermatomes

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8
Q

Major cause of cornea blindness?

A

HSV-1

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9
Q

Fatal sporadic encephalitis caused by?

A

HSV-1

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10
Q

How is infectious mononucleosis transmitted?

A

Close contact, saliva by kissing

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11
Q

Where does Epstein Barr bind to to cause infectious mono?

A

Complement receptor on epithelial cells and B cells

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12
Q

Where does Epstein barr spread to?

A

B-lymphoid tissues

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13
Q

Which cells on a smear appear atypical during an Epstein Barr virus infection?

A

T-cells

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14
Q

What test do you use for Mono?

A

Monospot

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15
Q

What is used in mono spot test?

A

Human anti-sheep RBCs agglutination

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16
Q

What will you see in blood of EBV patient?

A

Atypical lymphocytes (Anti-EBV T cells)

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17
Q

Biggest danger in EBV?

A

Spleen rupture

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18
Q

What is EBV common confused with?

A

Hodgkin’s disease

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19
Q

Diagnosis of EBV dependent on what?

A

Atypical lymphocytes
Positive heterophile reaction
Specific antibodies for EBV antigens

20
Q

Are the heterophiles antibodies specific for EBV?

A

No

21
Q

What causes X-linked lymphoproliferative disease?

A

Absence of gene called SAP (signaling lymphocyte activation molecule associated protein)

22
Q

CMV is part of what important mnemonic?

A

TORCHS

23
Q

In CMV what is important in diagnosis?

A

Urine sediment helps

24
Q

CMV associated with what from latent infection of leukocytes>

A

Reactivation of viral infection

25
Q

CMV infection in AIDs patients almost always accompanied by what infection?

A

Pneumocystis carinii

26
Q

How is HPV transmitted?

A

Direct contact

27
Q

Non-neoplastic strains of HPV associated with what?

A

Koilocytosis

28
Q

Neoplastic strains of HPV associated with what?

A

Viral intergration within the DNA

29
Q

Verruca vulgaris is known as whaT?

A

Common warts

30
Q

Difference between condyloma accuminatum vs condyloma late?

A

Late are plaques from syphilis

Accuminatum are genital warts

31
Q

Other Neoplastic viruses?

A

HHV8 (Karposi)
Hep B
Hep C

32
Q

Only vector for Ebola?

A

Human

33
Q

How does Ebola spread?

A

Human to human

34
Q

What is transmission for Ebola?

A

Nosocomial

35
Q

Where in the body does ebola hit?

A

Liver, viseral organ necrosis

36
Q

How is Hanta virus spread?

A

Human through rodent urine or feces

37
Q

How does Hanta virus present?

A

Acute hemorrhagic pulmonary syndrome

38
Q

Where does Hanta virus present?

A

Southwest (4 corners area)

39
Q

Where is Dengue?

A

Tropics and Africa

40
Q

Which mosquito spreads Dengue?

A

Aedes mosquito

41
Q

Dengue hemorrhagic fever is also known as what?

A

Breakbone fever

42
Q

Rare symptoms of Dengue?

A

Hemorrhagic phenomena, thrombocytopenia, dengue shock syndrome

43
Q

How does West Nile Virus spread?

A

Transmitted by mosquitoes to birds and mammals

44
Q

What is the major reservoir for West nile?

A

Birds

Humans are accidental

45
Q

Who is at risk for West Nile?

A

Elderly and immunocompromised

46
Q

Biggest danger of West Nile?

A

CNS symptoms involving meningitis, encephalitis, and meningoencephalitis

Pathology (18 decks)

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