HIV 3 Flashcards

1
Q

What is “the window” for seroconversion in HIV?

A

6-12 weeks

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2
Q

What is diagnosis based on?

A

Antibody presence to multiple HIV antigens such as gp120, gp41, gp 24

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3
Q

What is used in combination with serology?

A

WB test

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4
Q

What constitutes undetectable levels of viral RNA?

A

50 copies per ml

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5
Q

Increase in RNA levels indicates what?

A

Progression of disease

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6
Q

Strongest indicator of disease progression?

A

CD4 counts

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7
Q

Pattern of lymph nodes after chronic infection?

A

“Burned out with loss of lymphoid elements

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8
Q

HIV infection of CNS will show inflammatory infiltrate with what?

A

Microglial nodules and multinucleated giant cells

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9
Q

What forms Karposi’s sarcoma?

A

Proliferating mesenchymal spindle cells that form blood vessels

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10
Q

Why is serology not helpful in later stages of AIDs?

A

Patient cannot mount antibody response

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11
Q

Why is it common that patients show atypical symptoms when they have an infection?

A

Immune system is messed up

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12
Q

What symptoms at time of transmission?

A

Fever, malaise, and rash

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13
Q

Which repeated infections typically present?

A

Pneumocystis carinii, Mycobacterium avium, and cytomegalovirus

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14
Q

What can occur if patients suffer from HIV infection of microglial cells?

A

CNS dementia

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15
Q

What opportunistic viral infections are at risk for reinfection?

A

CMV, Herpes, Zoster

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16
Q

What opportunistic infections are at risk for latent reactivation?

A

Toxoplasmosis, TB, herpes zoster

17
Q

Karposi’s sarcoma associated with what infection?

A

HHV8

18
Q

Non-Hodgkin Lymphoma associated with what?

A

B-cell origin

19
Q

Invasive carcinoma of uternine cervix associated with what?

A

HPV infection

20
Q

Danger of antibodies and HIV?

A

Antibodies may allow virus into dendritic cells

21
Q

what is the major focus of HIV erradication efforts?

A

Prevention

22
Q

Cause of current HAART therapy complications attributed to?

A

Persistent inflammation and/or T-Cell dysfunction