Bacteria 3 Flashcards
Top pathogen contributing to domestically acquired food borne illnesses?
Norovirus
Top pathogen causing food borne illness that results in hospitalization?
Salmonella
Top pathogen causing food borne illness that results in death?
Salmonella
Danger of Listeria and E.coli O157:H7?
Less common but cause fatal disease
Incubation time for ingestion of enterotoxins?
Hours
Incubation time for infection by colonizing toxigenic organisms?
1-3 days
What happens to incubation time if enteropathic bacteria invade the gut wall?
Extended by days-weeks
How do enteropathic bacteria adhere to mucosal cells?
Pili and flagella
What enterotoxin produces T-cell super antigens?
Staph enterotoxins
Which enterotoxin produces cytotoxins?
Shiga toxins via Shigella and E.coli O157:H7
Which enterotoxin produces secretagogue toxin?
Vibrio cholerae
What happens after invasion and cytolysis of enteropathic bacteria?
Bloody diarrhea or dysentery
Clinically what causes a local disease from absorbed toxin?
Staph
Clinically what causes a systemic disease from absorbed toxin?
Botulism, o157:H7
What causes secretory diarrhea?
Cholera
What causes dysentery?
Shigella
what causes systemic illness?
Typhoid fever
What is Dysentery?
Loose stool+ Blood + leukocytes
At what point does Diarrhea become dysentery?
Mucosal invasion
What does Coliform mean?
Lactose fermenting
What is enterotoxin e.coli?
Watery traveler’s diarrhea
What is enterohemorrhagic e.coli?
Severe bloody colitis from o157:H7
What is enteroaggregative E.coli?
Pediatric diarrhea in impoverished nations
Source of enterohemorrhagic E.coli
Cattle and beef products
What is the dose size of enterohemorrhagic E.coli?
Small infectious dose of
How long does enterohemorrhagic E.coli last?
8 days
What does hemolytic uremic syndrome cause?
Acute renal failure via obstruction of glomeruli by microthrombi
How is Shigella spread?
Fecal/oral transmission, daycare centers
Does Shigella cause bacteremia to distant organs?
No
How large of a dose is needed to cause infection?
Pathogenesis of Cholera?
Enterotoxin causes secretion of isotonic fluid
What type of lesions does Cholera cause?
Non invasive
How does the stool look in cholera?
Rice water
What are the 3 types of Salmonella disease?
1) Typhoid
2) Enteric fever
3) Salmonella food poisoning
What does Typhoid infect?
Peyer’s patches
Most common Salmonella?
S. enteritidis and S. typhimurium
Turtles are disgusting
They are all infected with Salmonella and pass it in feces
Salmonella can cause what in children with sickle cell anemia?
Osteomyelitis and sepsis
Does Salmonella produce enterotoxin?
No
Where does Salmonella multiply?
Neutrophils and macrophages
Rose spots indicative of whaT?
Typhoid fever
What is associated with Guillain barre?
Campylobacter jejuni
What does stool look like in Campylobacter jejune?
Foul smelling with blood or exudate
Clostridium gram + or -?
+
Clostridium tetani most commonly associated with what?
Puncture wounds
What is the neurotoxin of Tetanus?
Tetanospasmin
What do you get from raw seafood?
vibrio vulnificus or vibrio parahaemolyticus
