Viral illness 1

Question 1

How are viruses transmitted?

Answer 1

Secretions or cells

Question 2

How do viruses damage the host cell?

Answer 2

Entering the cell and replicating at the host expense

Question 3

How does Epstein Barr Virus attach to host cell?

Answer 3

Complement CD21 receptor on macrophages

Question 4

How does Rabies attach to host cell?

Answer 4

Acetylcholine receptor

Question 5

How does Rhinovirus attach to the host cell?

Answer 5

ICAM-1

Question 6

What special enzymes or promoter element is required for JC virus to get in?

Answer 6

Oligodendrocytes

Question 7

Hallmark of viruses in infected cells?

Answer 7

Morphologic alterations

Question 8

What host immune responses will be used to deal with viruses?

Answer 8

Antibody and cell mediated responses

Question 9

Function of antibodies?

Answer 9

Prevent viremia and prevent re-infection

Question 10

How does the antibody neutralize the virus?

Answer 10

Prevents attachment

Interferes with viral uncoating

Question 11

How can antibodies be used in disease states?

Answer 11

Glomerulonephritis
Arthralgias
Enhance cell uptake and promote infection

Question 12

In the cell mediated response how does the process work?

Answer 12

Mediated by CD8, needs CD4 for initial reaction

Question 13

Which MHC class does CD8 target?

Answer 13

1

Question 14

NK cells go after what?

Answer 14

Virally infected cells not displaying MHC 1

Question 15

Cell mediated response releases interferon y (gamma), what’s it do?

Answer 15

Inhibits RNA translation which hurts viruses more than us

Question 16

Interferons alpha and beta do what?

Answer 16

Activation of antiviral responses

Question 17

Two main patterns of viral infection?

Answer 17

Local and Distant

Question 18

Incubation time for local viral illness?

Answer 18

Days

Question 19

Incubation time for distant viral illness?

Answer 19

Weeks

Question 20

Lesions in local viral illness are where?

Answer 20

Site of entry

Question 21

Lesions in distant viral illness involve what?

Answer 21

Immune mediated damage

Question 22

What 3 features determine pathology of virus?

Answer 22

1) Distribution of organism
2) Cytopathic features of virus
3) Host immune reaction

Question 23

What is characteristic of cytopathic features

Answer 23

Inclusion bodies

Question 24

In what viral illness will I see inclusion bodies in the nucleus?

Answer 24

Herpes

Question 25

In what viral illness will I see inclusion bodies in the cytoplasm?

Answer 25

Rabies (negri bodies)

Question 26

In what viral illness will I see inclusion bodies in nucleus and cytoplasm?

Answer 26

CMV

Question 27

Difference between bacterial and viral infection?

Answer 27

No abscesses

Question 28

Councilman bodies found in what?

Answer 28

Hepatitis apoptotic cells

Question 29

Warthin-Finkeldey indicated by?

Answer 29

Measles giant cells

Question 30

Ground glass cytoplasm found in?

Answer 30

Hepatitis

Question 31

Kailocytosis indicative of what?

Answer 31

Papilloma virus

Question 32

What is seen in CMV?

Answer 32

Distinct intranuclear and ill defined cytoplasmic inclusions

Question 33

What is seen in herpes/varicella?

Answer 33

Cowdry type A intranuclear bodies

Question 34

What is seen in Rabies?

Answer 34

Negri bodies

Question 35

What is seen in adenovirus?

Answer 35

Smudge cells and Cowdry type A intanuclear inclusion bodies