vascular system Flashcards
coagulation: explain the processes of coagulation, platelet activation and the actions of fibrin
1
Q
3 stages of coagulation
A
initial -> amplification -> propagation
2
Q
what happens in initiation
A
TF presentation, leading to prothrombinase-mediated formation of fIIa (thrombin)
3
Q
what happens in amplification
A
fIIa-mediated platelet activation -> ADP activates P2Y12 receptors -> COX and GPIIb/IIIa
4
Q
what happens in propagation
A
thrombin-mediated conversion of fibrinogen to fibrin strands
