pharmacokinetics

Question 1

4 sections of drug journey between administration and removal

Answer 1

ADME: absorption, distribution, metabolism, excretion

Question 2

why is ADME important

Answer 2

determines dose of drug available to tissues to produce effect you want

Question 3

7 routes of drug administration, journeys in body and excretion

Answer 3

dermal (skin to sweat and oil); intramuscular, subcutaneous, intraperitoneal, intravenous (blood and lymph to kidneys, bladder and urine, or to ECF and to fat or to organs in bone or soft tissue); inhalation (lungs to blood and lymph or exhaled); ingestion (to GIT and to faeces or to liver, which goes to blood and lymph or to bile and back to GIT)

Question 4

define systemic and drug examples

Answer 4

entire organism to tissues deep within the body (e.g. to get into brain must get into bloodstream as can’t inject straight into brain); cannabis, aspirin, nicotine

Question 5

define local and drug examples

Answer 5

restricted to one area of organism; salbutamol, antacid, betnovate

Question 6

define enteral and which drug route these are

Answer 6

enter GIT: ingestion

Question 7

define paraenteral and which drug routes these are

Answer 7

outside GIT: dermal, intramuscular, subcutaneous, intraperitoneal, intravenous, inhalation