general autonomic nervous system pharmacology topic Flashcards
cholinergic / noradrenergic transmission: summarise the processes involved in the biosynthesis, release and metabolism of acetylcholine, noradrenaline and adrenaline and identify potential targets for pharmacological manipulation of cholinergic/adrenergic transmission
1
Q
biosynthesis and metabolism of neurotransmitters
A
precursor from diet, converted to neurotransmitter, packaged into vesicle, exocytosis after Ca2+, into synaptic cleft, binds to and activates receptor, short-lived effect, degradation of neurotransmitter
2
Q
acetylcholine
A
acetyl CoA + choline -> ACh and CoA; vesicle; released; acetylcholinesterase breaks down to choline and acetate
3
Q
noradrenaline
A
tyrosine -> DOPA (tyrosine hydroxylase) -> dopamine (DOPA decarboxylase) -> broken down in vesicle to noradrenaline (by dopamine B hydroxylase) -> released and reuptaken by membrane protein then broken down inside (MAO-A and COMT), so hangs around longer
