Unit 4 - Pancreas Labs Flashcards
History: Tissue from a 0.25 year old cat that was adopted from the humane society two weeks ago. This animal had a history of lethargy, anorexia and a distended abdomen
Describe this lesion:
Throughout the serosal surface of the intestine, there are numerous, multifocal white to cream-colored, 1-3mm diameter firm, tan foci which occasionally track along blood vessels. Similar firm, 1-2 mm in diameter tan foci are scattered throughout the mesentery.
History: Tissue from a 0.25 year old cat that was adopted from the humane society two weeks ago. This animal had a history of lethargy, anorexia and a distended abdomen
Microscopically, foci on the serosal surfaces of the intestine are composed of large numbers of macrophages admixed with neutrophils and fibrin. Based on the microscopic description, provide an appropraite morphologic diagnosis for the intestinal lesions:
Intestinal serosa & mesentery: Chronic, multifocal, fibrinous and pyogranulomatous serositis/peritonitis
History: Tissue from a 0.25 year old cat that was adopted from the humane society two weeks ago. This animal had a history of lethargy, anorexia and a distended abdomen.
Name the disease.
Feline infectious peritonitis (FIP) – wet form (would have an effusion in the abdomen)
History: Tissue from a 0.25 year old cat that was adopted from the humane society two weeks ago. This animal had a history of lethargy, anorexia and a distended abdomen.
What type of virus causes this disease & what is the long term prognosis?
Caused by a coronavirus. The disease is invariably fatal.
History: Tissue from a 0.25 year old cat that was adopted from the humane society two weeks ago. This animal had a history of lethargy, anorexia and a distended abdomen.
What Clin Path findings would provide support for your diagnosis?
Total serum protein will be greater than 7.8 g/dl
A:G ratio will be greater than 0.8
History: Tissue from a 1 year old CM siamese mix. Healthy kitten for the first half of his life, but has had a chronic history of diarrhea, weight loss, and lethargy for the last 4 months.
Describe the lesions:
Liver: The liver has multifocal poorly demarcated random pale foci 2-5 mm in diameter scattered thoughout the parenchyma.
Kidney: The peri-renal fat of the left and right kidney had multifocal to coalescing yellow prominent foci through-out. The cortical surface of both kidneys also contained multifocal to coalescing small yellow foci that were approximately 1-3 mm in diameter.
History: Tissue from a 1 year old CM siamese mix. Healthy kitten for the first half of his life, but has had a chronic history of diarrhea, weight loss, and lethargy for the last 4 months.
Provide an appropriate morphological diagnosis:
Liver: moderate, chronic, multifocal nodules
Kidney: mild, multifocal renal nodules.
History: Tissue from a 1 year old CM siamese mix. Healthy kitten for the first half of his life, but has had a chronic history of diarrhea, weight loss, and lethargy for the last 4 months.
What is your top differential for these lesions?
Dry form of FIP
History: Tissue from a 1 year old CM siamese mix. Healthy kitten for the first half of his life, but has had a chronic history of diarrhea, weight loss, and lethargy for the last 4 months.
This form of this disease is called the great mimicker, because it is on our differential list for clinical signs in multiple organ systems. In young cats, list the organ systems for which this disease is one of our differentials.
- Abdominal effusion
- Renal dz
- CNS dz
- Ocular dz
- Liver dz
- Respiratory dz
History: Tissue from a 13 year old cat with cranial abdominal pain, vomiting, and weight loss.
Describe this lesion:
Omentum: The omentum was diffusely showered with round, firm, cream-colored nodules that varied in size from 1-8 mm in diameter. Similar nodules were focally present on the serosal surface of the adjacent intestine. The omentum is diffusely red in color (hyperemic)
History: Tissue from a 13 year old cat with cranial abdominal pain, vomiting, and weight loss.
Provide a morphological diagnosis:
Chronic, multifocal omental and serosal masses
History: Tissue from a 13 year old cat with cranial abdominal pain, vomiting, and weight loss.
An impression smear of the lesions reveals a bizarre population of epithelial cells. What is your most likely diagnosis?
These are likely peritoneal implantation metastasis of a carcinoma
History: Tissue from a 13 year old cat with cranial abdominal pain, vomiting, and weight loss.
Describe the process that can result in these lesions and list three primary tumor sites that may have led to these lesions.
Invade through serosa ⇒ small clusters of tumor cells exfoliate into peritoneum ⇒ implant on the serosa of a variety of peritoneal viscera (diaphragm, omentum, mesentery, spleen, liver, intestinal serosa, etc.).
Peritoneal implantation metastases are most commonly identified in association with pancreatic, hepatic, and gastrointestinal tumors.
History: Tissue from a 12.04 year old obese female miniature Schnauzer with an acute history of vomiting, anorexia, and abdominal pain.
Describe the lesions:
Pancreas: The distal limb of the pancreas was diffusely firm, cream/white in color, and had a nodular surface. There were extensive adhesions between the pancreas and omentum that could not be easily broken down by manual manipulation. An approximately 4.5 cm region in the central portion of the pancreas was dark red in color (hemorrhagic) and covered by tan friable material (fibrin). When this region in sectioned, centrally there is irregular grey tan friable tissue (necrosis) There were small foci that were soft and tan in color within the areas of hemorrhage (necrosis). These areas of hemorrhage and necrosis involved approximately 40% of the pancreas.
History: Tissue from a 12.04 year old obese female miniature Schnauzer with an acute history of vomiting, anorexia, and abdominal pain.
Provide appropriate morphologic diagnoses:
- Severe, diffuse, chronic, fibrosing pancreatitis
- Acute, focally extensive fibrinous and necrohemorrhagic pancreatitis
- . Acute, severe, multifocal paripancreatic fat necrosis