TREATMENT

Question 1

◼May cause aseptic meningitis and
cognitive dysfunction
◼Monitor for renal, hepatic, GI side effects
◼monitor CBC, LFT’s, BUN/Cr, urinalysis

Answer 1

NSAIDS

Question 2

◼ Relatively low doses for treatment of Constitutional sx,
arthritis, cutaneous manifestations, serositis
◼ High doses for treating nephritis, cerebritis,
hematologic abnl, vasculitis
◼ Mainstay of therapy during pregnancy
◼ Side effects: osteonecrosis, hyperglycemia, HTN,
hyperlipidemia, osteoporosis

Answer 2

Corticosteroids

Question 3

◼ Prevent flares
◼ Effective for rx of mild skin disease, arthritis,
mild serositis, constitutional sx
◼ May have antithrombotic effects, lipid lowering
effects
◼ Monitor for macular damage; fundoscopic/
visual field checks q6months

Answer 3

Hydroxychloroquine (plaquenil)

Question 4

◼Purine analogue inhibiting nucleic acid
synthesis; affects humoral and cellular
immunity
◼Steroid sparing agent for rx of non-renal
manifestations of SLE, or nephritis
◼Bone marrow and GI toxicity

Answer 4

Azathioprine (Imuran)