PART I Flashcards
prevalent, systemic inflammatory disease with potential of high morbidity both in articular and extra articular manifestations
RA
most important clinical features?
symmetrical, small joint pain and morning stiffness with joint swelling
what are the markers in diagnosis?
RF
anti-CCP antibody
inflammatory markers
standard initial tx?
methotrexate
major characteristics describing joint affected by RA?
bone erosion
swollen inflamed synovial membrane
cartilage wears away
reduced joint space
major alleles indicated in RA?
HLA-DRB1; DR4, DR14, DR1 beta chains having higher RA and anti CCP positivity
major alleles indicated in RA?
HLA-DRB1; DR4, DR14, DR1 beta chains having higher RA and anti CCP positivity
antibody directed?
present in approx how many RA patients?
against FC portion of IgG
80%
secondary causes of RA?
infectious endocarditis, TB, Hep C, sarcoidosis, IBD, other autoimmune diseases
episcleritis is a major feature of RA, also pulmonary lung diseases, T/F?
T
what is this RA pulmonary manifestations?
homogenous mononuclear infiltrate
ground glass infiltrate on HRCT
better prognosis
nonspecific interstitial pneumonitis (NSIP)
non productive cough and dyspnea
honey combing of HRCT
worse prognosis
these are characteristics of what pulmonary manifestation?
usual interstitial pneumonitis
goals of therapy?
treat early
treat: pain, joint damage, extra articular disease, disability, premature death
treat to target
types of DMARDs?
methotrexate hydroxychloroquine sulfasalazine leflunomide minocycline
significance of TNF inhibitors?
expressed on surface of macrophages
binding to receptors
works with methotrexate
receptor blocker
-etanercept
monoclonal AB
- infliximab
- adalimumab
- golimumab
- certilizumab
B cell targeted therapy?
T cell targeted therapy?
rituximab
abatacept
significance of Jax Stat?
composed of:
4 non receptor protein tyrosine kinases
7 inactive cytoplasmic proteins
needed in proinflammatory signaling
JAK1/JAK3 inhibition
JAK1/JAK2 inhibition
JAK1 inhibition
tofacitinib
baricitinib
upadacitinib
TNF alpha blockers can lead to?
are fungal infections increased? T/F
which hepatitis?
TB
T
B
this is important in inducing apoptosis in tumor cells?
increased risk of what cancers?
TNF
melanoma and non melanoma skin cancers
