PAGETS DISEASE

Question 1

osteitis deformans
focal disorder of bone metabolism
acerbated rate of bone turnover and remodeling 
pain 
bone deformities

Answer 1

Paget disease of bone

Question 2

disease of aging bone > 55yrs old

genetic and environmental causes

Answer 2

paget disease of bone

Question 3

affected areas of bone in pagets?

Answer 3

pelvis
femur
lumber spine
skull
tibia

Question 4

what kind of pain most common?

Answer 4

bone pain

• osteoarthritis
• nerve compression
• pseudofracture

Question 5

diagnosis technique for pagets?

Answer 5

alkaline phosphatase
radiographs
radionuclide bone scan

Question 6

evals based on?

Answer 6

LFTs
vit D levels
calcium and phosphate levels

Question 7

tx?

Answer 7

pain relief
reduce rate of bone remodeling and enhance deposition of normal bone
decrease vascularity of bone
slow disease progression

Question 8

indications for tx?

Answer 8

bone pain
symptomatic nerve compression
osteolytic bone lesions
fx through pagetic bone lesion

Question 9

tx meds?

Answer 9

bisphosphonates
zoledronic acid (first choice)

Question 10

indications for surgery?

Answer 10

corrective osteotomy for long bone deformity

pathologic fx fixation

joint arthroplasty

spinal stenosis

resection of bone tumors

hypervascularity of bone may cause bleeding