Tourette Syndrome

Question 1

Tourettes syndrome criteria (2)

Answer 1

at least 2 motor tics and at least 1 vocal (phonic) tic have been present does not have to be at same time

Question 2

Children and Tourettes diagnosis to be mindful of because

Answer 2

Children’s motor tics are fairly common and can be temporary

Question 3

Tics can wax and wane in frequency but have occurred for more than ______

Answer 3

1 year

Question 4

Tics usually start before the age of

Answer 4

18

Question 5

Neurotransmitters involved for tourettes syndrome (5)

Answer 5

Dopamine*
NE,
Serotonin,
glutamate
GABA

Question 6

Pharmacologic management

Answer 6

atypical antispychotics

Question 7

FDA approved medications 3

Answer 7

Haloperidol
Pimozide
Aripriprazole

Question 8

For Tourettes what medications can help control behavior symptoms such as impulse control and rage attacks (2)

Answer 8

clonidine (catapres, Kapvay)
Guanfacine (Intuniv)

Question 9

What happens to dopamine to cause tourettes?

Answer 9

Hyperactivity

Question 10

Which is most preferable for treatment in children, guanfacine or clonidine? why? 4

Answer 10

Guanfacine
longer half-life- taken once daily simpler schedule
fewer sedative effects
better tolerability lower side effects

Question 11

clonidine side effects (3)

Answer 11

dry mouth, fatigue, irritability