Antipsychotics

Question 1

First-generation antipsychotics AKA typical (4)

Answer 1

Haloperidol
Fluphenazine
Chlopromazine
Thioridazine

Question 2

Mechanism of typical first gen antipsychotics

Answer 2

D2 receptor inhibitor

Question 3

Receptor profile for first gen antipsychotics (3)

Answer 3

Histamine 1, alpha 1, mvuscinarinic 1

Anti- HAM (first and second generation)

weight gain, sedation, orthostasis, decrease tension, priapism (Decreased sex drive) , dry mouth,

Question 4

2nd generation antipsychotics a typical (7)

Answer 4

Risperidal
olanzapine
ziprasidone
clozapine
quetiapine
ariprazole
lurasidone

Question 5

Mechanism of action for 2nd generation antipsychotics

Answer 5

block D2 and Serotonin (5HT2a)

Question 6

2nd generation antipsychotics are better because?

Answer 6

decrease EPS r/t 5HT2A inhibition

Question 7

S/E of 2nd generation antipsychotics (4)

Answer 7

metabolic syndrome, weight gain, increased diabetes, increased cholesterol

Question 8

Risperidone can cause what ADR?

Answer 8

Hyperprolactinemia (highest incidence) milk out of breast

Question 9

HTN with MAOIs why? (4)

Answer 9

isocarboxiazid
phenelzine
selegiline
tranylcypromine foods

tyramine is a precursor to NE

Question 10

Hypertensive crisis is life threatening how to reverse it? (3)

Answer 10

Stop MAOI
give phentolamine
stabilize fever

Question 11

s/s of hypertensive crisis (7)

Answer 11

BP 180/120 mmhg or >
explosive headache (occipital region)
facial flushing (redness)
Palpitations
pupil dilation
diaphoresis
fever

Question 12

How do most antipsychotics work

Answer 12

decrease dopamine in mesolimbic pathway

Question 13

What makes an antipsychotic medication “atypcial”

Answer 13

a 5HT2A antagonist means the drug binds to the 5-HT2A receptor and prevents serotonin from activating it