Enzymes, Inducer, Inhibitors

Question 1

Enzyme Inducers

Answer 1

D for decrease, decrease serum levels of other medications like tobacco and carbamazepine

Question 2

Someone on Olanzapine starts smoking what should you do to the dose

Answer 2

increase dose because smoking increase the metabolism of the drug thus decreasing the effectiveness

Question 3

Someone who stops smoking on olanzapine what should you do

Answer 3

decrease dose

Question 4

Is smoking an induce or inhibitor

Answer 4

inducer - decreases effectiveness by increasing the metabolism of the drug

Question 5

Tobacco is an important inducer of what enzyme

Answer 5

1A2

Question 6

A person who is on clozapine and doesn’t smoke will have what in comparison to someone who smokes

Answer 6

increased serum levels

Question 7

Inhibitors (12) SICKFACES.COM

Answer 7

Sodium valproate
Isoniazid
cimetidine
ketoconazole
fluconazole
alcohol (acute)
chloramphenicol
erythromycin
sulfonamide
ciprofloxacin
omeprazole
metronidazole

Question 8

Inducers Bullshit CRAP GPS induces my rage (10)

Answer 8

Barbiturates (sedatives)
St johns worth
carbamazepine
Rifampin
chronic alcohol use
phenytoin
griseofulvin
phenobarbital
sulfonylureas
smoking cig

Question 9

How does liver detox affect enzyme activity ?

Answer 9

affects enzyme activity and first-pass metabolism - potential toxic drug levels

Question 10

Enzyme inhibitors

Answer 10

hi= high serum levels increases serum levels of other drugs that are substrates of that enzyme

Question 11

Clarithyromycin and ketonazole are examples of

Answer 11

inhibitors

Question 12

Clozapine is an atypical antipsychotic medication that is metabolized to a major extent by the cytochrome _____ enzyme _____.

Answer 12

P450 and CYP1A2

Question 13

Nicotine is metabolized by the enzyme

Answer 13

CYP2A6

Question 14

enzyme inducers (decrease) can ________ serum level of other drugs that are substrates of that enzyme, possibly causing _______ drug levels.

Answer 14

decrease
subtherapeutic

Question 15

Depakote is a very strong _____ (type of inducers)

Answer 15

inhibitors

Question 16

If the patient is taking an inducer and inhibitor such as Tegretol (inducer) and doxycycline (inhibitor)

Answer 16

inhibitors take over the inducers- so if the client is taking the doxycycline, it can cause high serum levels of Tegretol, so you want to decrease the dose of Tegretol.

Question 17

doxycycline, erithromycin, clarithromycin are all examples of

Answer 17

inhibitors they take over inducers

Question 18

When Lamictal is taken with Depakote there are significant interactions, why?

Answer 18

Depakote is a CYP enzyme inhibitor, meaning it inhibits the metabolism of lamotrigine, leading to an INCREASE in lamotrigine levels in the body.

Question 19

Lamictal toxicity can cause

Answer 19

steven johnsons syndrome

Question 20

when Lamictal is taken with valproate typically the laminate dose is adjusted by

Answer 20

decreasing it

Question 21

If patient is taking St John’s Wort it is in inducer and Digoxin (heart failure) the St John’s wort can do what to the Digoxin level?

Answer 21

it can decrease the serum levels of Digoxin
so PCP may need to increase dose for effectiveness