NEED TO KNOW Flashcards

1
Q

Metoprolol (Lopressor) should not be used with (3)

A

Paroxetine, Fluoxetine, or Bupropion due to risk of serious adverse effects like hypotension and bradycardia

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2
Q

What supplements can improve depressive symptoms (4)

A

B12, B6, Folate, Omega 3 fatty acid

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3
Q

What medications can cause QT prolongation (4)

A

Ziprasidone
Quetiapine
Haloperidol
Citalopram

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4
Q

What medications are LESS Likely to prolong QT interval (3)

A

aripriprazole
lurasidone
olanzapine

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5
Q

Least sedating SSRIs (2)

A

Lexapro (escitalopram)
Fluoxetine

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6
Q

Safest SSRIs for patients with heart issues

A

sertraline
escitalopram

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7
Q

Symptoms of serotonin discontinuation syndrome (6)

A

muscle soreness
achiness
n&v
fatigue
lethargy
agitation

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8
Q

Effective tx for serotonin discontinuation syndrome

A

resume taking the antidepressant at the previously prescribed dose

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9
Q

Mood stabilizer with least weight gain

A

Lamictal

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10
Q

Migraine medications

A

Triptans and sumatriptan (imitrex)

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11
Q

What conditions present likely with homicidal ideation

A

Antisocial personality d/o very common

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12
Q

why do studies online show more efficacy for antidepressants with adults versus children

A

because studies contain more adults not children

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13
Q

Medications that can cause mania (4)

A

steroids like prednisone and dexamethason
Disulfiram (antabuse)
Isoniazid (INH)
Antidepressants for bipolar

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14
Q

Medications that can cause depression (9)

A

steroids **
liothyronine
beta blockers
interferon
Isotretinoin
retroviral drugs
antineoplastic drugs
benzodiazepines
progesterone

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15
Q

Paradoxical effects

A

prescribe patient with anxiety and agitation with Geodon, but instead of it helping the anxiety- it makes it worse- so patient is experiencing the opposite effect

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16
Q

Risk factors for osteoporosis 5

A

smoking, drinking caffeine, lack of calcium i diet, and vitamin D, lack of weight-bearing exercise

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17
Q

if pt has RA what is a common test

A

erythrocyte sedimentation rate

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18
Q

if pt is positive for RA what happens to teh erythrocyte sedimentation rate

A

increased

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19
Q

the infant is producing a shrill cry (high pitch) can be due to

A

can be due to increased intracranial pressure

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20
Q

postmenopausal women have low sex drive can be due to

A

hormonal decrease in testosterone, progesterone, and estrogen, and reduced pelvic blood flow

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21
Q

what hormonal therapy can help menopausal depression

A

estrogen and progesterone

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22
Q

what kind of diet helps with depression

A

low fat diets

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23
Q

who is more prone to alcohol related liver damage

A

women because they have lower levels of alcohol dehydrogenase, which is the enzyme that metabolizes alcohol

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24
Q

Macrocytic normachromic anemia you want to check

A

b12 and folic acid levels because b12 deficiency can lead to symptoms

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25
Q

major cause of microcytic anemia is

A

iron deficiency

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26
Q

what happens with low levels of iron

A

less oxygen gets to the cells keeping them from properly functioning and often leads to fatigue, weakness and anxiety

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27
Q

protects patients against unlawful hospitalization- esp mental illness, if they were hospitalized for no just reason they can use this to leave AMA

A

habeas corpus

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28
Q

in order to provide evidenced based care we need access to

A

current journal articles

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29
Q

you wanted the patient to review timeline but they couldn’t remember within a specific time frame what can you do

A

ask more specific questions or ask questions that link memorable events

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30
Q

if you wanted to educate patient about a medication you must first assess what

A

patients knowledge of the medication and their beliefs around it

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31
Q

disseminated encephalomyelitis symptoms

A

nervous system disorder- headache, confusion, ataxia, asymmetrical body movements

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32
Q

if patient has disseminated encephalomyelitis may need

A

neuroexam

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33
Q

if you are trying to implement a policy that will affect nurse practitioners nationwide you want to

A

create an online forum so questions and concerns can be addressed there

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34
Q

if you want to implement new policy but your coworkers are against the new policy what can you do

A

prove how the new policy can improve quality of patient care

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35
Q

PICOT QUESTIONS stands for

A

Population problem patient
intervention issues interest
comparison
outcome
time

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36
Q

starting investigation for nursing what should you do

A

start with PICOT question

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37
Q

evidence from a systemic review or meta analysis of all relevant randomized controlled trials or evidence-based clinical practice guidelines based on a systematic review of RCTs or three or more RCTs of good quality that have similar results

A

level 1

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38
Q

evidence obtained from at least one well designed RCT

A

level 2

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39
Q

how to ensure continuous improvement of quality of care in an outpatient clinic

A

develop an instrument to monitor clinical outcomes

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40
Q

how to ensure continuous quality improvement when treating patients with mental illness like depression and anxiety

A

use a rating scale to determine baseline scores and at regular intervals during treatment

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41
Q

how to monitor clinical progress

A

standardized rating scales

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42
Q

Diabetic keto acidosis is common complication of type 1 dm symptoms:

A

kussmaul respirations rapid and deep
fruity-scented breath
excessive thirst and urination
fatigue
confusion

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43
Q

medication for enuresis

A

desmopressin to reduce urine production

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44
Q

night time bedwetting non pharmacological interventions

A

set alarm for night time voiding and use moisture alarms

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45
Q

looking up patients info on social media is

A

violating their trust

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46
Q

patient has been taking a medication and is stable but then FDA releases a black box warning of medication so waht do you do

A

research benefits and risks of continued use and make decision with patient

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47
Q

off label you want to make sure to provide patient with

A

FULL DISCLOSURE add evidence supporting of off label use document risks and pros

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48
Q

sleep apnea risk factors

A

smoking,
excess weight
obesity
diabetes
high BP
narrowed airways

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49
Q

reflective practicing

A

is a debriefing strategies after an event or cause with the goal of improving practice

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50
Q

pt use to take on pill of clonazepam for two years but now is requesting two pills to achieve the same effect of the one pill

A

tolerance - decrease effect with continuous use of the SAME dose over time

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51
Q

legal telemed

A

confidentiality concerns
medical errors
jurisdiction authority over licensure always verify where the patient is (if the client moves to another state in a state not under your license that is illegal)

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52
Q

pt with Substance use disorder in IOP when do you transfer them to less IOP

A

patient is taking responsibility for their actions and has developed coping skills

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53
Q

med errors what is the first thing you want to do to develop policy

A

assess common types of med errors and then assess learning needs of staff

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54
Q

MMSE score

A

0-30

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55
Q

MMSE mild score

A

21-24 Mild cognitive impairment possibly early to mild alzheimers

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56
Q

MMSE Moderate score

A

10-20 moderate Alzheimer disease

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57
Q

MMSE normal score

A

25-30

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58
Q

MMSE severe score

A

0-9 severe alzheimer

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59
Q

SLUM normal score

A

27-30

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60
Q

SLUM mild score

A

21-26

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61
Q

Slum dementia score

A

0-20

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62
Q

MoCA normal score

A

26-30

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63
Q

MoCa mild cognitive impairement

A

18-25

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64
Q

moderate cognitive impairement MoCA

A

10-17

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65
Q

MoCA less than 10 means

A

severe cognitive impairment

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66
Q

if someone has Alzheimers they should not be scoring a

A

20-25 it should be reassessed

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67
Q

PHQ moderate score depression

A

10-14

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68
Q

HAM D moderate score depression

A

14-18

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69
Q

MADRS moderate score depression

A

20-34

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70
Q

Beck moderate depression

A

19-29

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71
Q

HAM for anxiety moderate range

A

18-24

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72
Q

GAD moderate

A

10-14

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73
Q

COWS opioid moderate score

A

13-24

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74
Q

when to start tx on COWS score

A

> 7

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75
Q

CIWA ETOH moderate score

A

16-20

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76
Q

when to start tx on CIWA

A

8 and above PRNS only

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77
Q

when to start meds for CIWA score

A

15 and above (valium, Ativan, or librium

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78
Q

what can you give patient scoring a mild on COWS 5-12?

A

clonidine

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79
Q

when can you give buprenorphine or suboxone on COWS

A

moderate to severe 13 and above

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80
Q

Suboxone is

A

buprenorphine and naloxone

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81
Q

methadone can cause

A

cardiac issues not first choice

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82
Q

clonidine common s/e

A

drowsiness more than buprenorphine or suboxone

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83
Q

Collecting data can look like? (4)

A

vital signs, ordering CMP, lab results, and literature search

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84
Q

The assessment process includes: (3)

A

Identify, survey, and collect data

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85
Q

When does behavioral management and support begin?

A

AFTER pt is admitted

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86
Q

with cultural questions what should you always do first?

A

Always respect before assess or intervention with cultural questions

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87
Q

What medication can exacerbate tics? and what would an alternative be especially for an adolescent?

A

Stimulants exacerbate tics and another alternative is guanfacine

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88
Q

Be wary of absolutes

A

all, only, always, every, must, never, none, everything, nothing, etc 🡪 usually wrong. The ONLY answer option is USUALLY WRONG.

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89
Q

If a question has 3 interventions and 1 assessment, most likely the answer is the assessment.

A
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90
Q

Questions that use adjectives like “priority” and “initial action” test your ability to prioritize.
How would you usually prioritize?

A

-ABC

-Maslow’s hierarchy of needs (physiologic needs (food, water, warmth, rest, safety and security)

-Nursing Process (assessment before intervention) Assessment is collecting data
- Urine drug screen, Vital signs, CMP, literature data etc

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91
Q

What do you do if a patient tells you they are a victim of abuse?

A

1st, reassure them of their safety and provide them with an environment of safety- Do this before assessing them or intervening

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92
Q

A child comes in with the parents and the child tells you they have been sexually abused, what do you do?

A

You will interview the child separate from the parents FIRST and then report to CPS 2nd

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93
Q

A Child comes in alone and has a toy, based on the play with this toy in a sexual way you suspect sexual abuse what is your next action?

A

You will contact and report to CPS immediately. Do not start investigating with parents or caregivers

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94
Q

You work as a PMHNP inpatient and want to discharge a patient, what must you confirm first?

A

You need to ensure patient can stay safe and cope effectively

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95
Q

You work inpatient and you want to interview a patient, what is the best way to interview them?

A

Do not interview the patient in their room, - this could be an unsafe environment. Do not interview in the day room.

CORRECT-Interview in a private area with the door open/partially open. SAFETY over PRIVACY
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96
Q

How do you build a rapport with teens / adolescents 12-20 years old

A

Let them know their information is confidential with exceptions to confidentiality such as danger to self or to others. If interviewing a teen, do not interview with parents in the room. Ask the parents to stay in the waiting room.

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97
Q

When a teen tells you they are attracted to the same gender or dating someone of the same age,

Adolescents have a right to _____

A

No need to tell parents.
- You may tell parents if they are dating someone older or younger but not if they are the same age.
-You are advocating for adolescents and they have the right to CONFIDENTIALITY.
-Parents may feel like they have the right to know everything and this can create an ethical dilemma. However, the teen has a right to confidentiality (not privacy)

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98
Q

Collaboration vs delegation in answering questions:

A

Interprofessional collaboration is encouraged. If a question had collaborate🡪 this is most likely right
-When answering, choose options you are actively getting involved
-Delegating is usually wrong
-Collaboration with the nurse manager or dietician is usually correct option (Look for KEY WORD collaborate)

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99
Q

Call provider to discuss patient care in interprofessional collaboration.
Example: You notice a lot of women attempt suicide post partum because OB doctor doesn’t do risk assessment before discharge

A
  • Collaborate with OB doctor and recommend the OB doctor does suicide risk assessment before discharging patients
  • Discrepancy in care by OB, Collaborate to correct the gap in care
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100
Q

You are discharging a patient to rehab and they request labs. Do you print labs and give to patients? Do you get informed consent and fax labs?

A

Get informed consent and fax the labs.
- Get actively involved helping patients.
-Printing labs and giving them to patients increases the chance of labs being lost.

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101
Q

Is a medical evaluation within the PMHNP scope?

A

NO- -Only correct if referring to someone else to do a medical evaluation.
-Is there something I could do within my scope of practice for this patient BEFORE referring out?
-Referring out is usually the last part

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102
Q

For example, a 15-year-old comes into the office and tells you they inhaled acetone and are feeling weird. As an NP, what is your priority action?

A

-Correct thing is to do a urine drug screen (UDS).
-Patient could be at increased risk of using other substances
-Don’t need to refer out for emergency evaluation yet; Do the UDS and see if they are using other substances.

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103
Q

Cultural Syndrome (something that is normal in that culture)- what is the next action?

A

-Don’t need to start on psychotropics
-Validate symptoms based on culture
-Offer brief supportive therapy

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104
Q

Cultural question: Somatic complaints of pain “ My pcp hasn’t found any medical reason for this” What do you do?

A

Validate symptoms based on cultural context.
Interpret the cultural meaning of pain, Ask patient, understand their pain based on cultural significance of pain.

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105
Q

Cultural assessment = cultural formulation interviews: (3)

A

-Clarify the meaning of illness or predicament
-Contextualize their situation in their local world
-Empower the patient

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106
Q

If you want to provide psychoeducation to patient from a specific culture what do you do? (2)

A

-Information should be based on developed cultural concepts specific to their culture
-Pt diagnosed w schizophrenia, based information on cultural context 🡪 benefits of meds, psychoeducation

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107
Q

Community Education: with multiple cultures what is your approach?

A

-Health promotion in the community.; Not everyone who lives in the community is from the same culture -Multicultural community. Ex: Long beach
-Based on the assessment of identifying people in the community who are of different ethnicities 🡪 Provide multicultural education/ teaching. (don’t use the same assessment parameters for every household. Use ETHNO SPECIFIC assessment parameters.

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108
Q

The ethnic group in the US with the Highest rate of Suicide and suicide attempts.

A

Native Americans

109
Q

RESPECT related to culture is important
-Respect BEFORE assessment or intervention
-Respect the interpretation of what is causing mental illness
Example:

A

Native Americans think mental illness of substance use can be caused by an imbalance between individual relationships with the world. (Respect their interpretation of what is causing their illness)

110
Q

The Patient wants you to release information to the traditional healer what do you do?

A

yes it is ok to release to the healer or to include the healer in their care 🡪 AFTER INFORMED CONSENT is obtained 🡪 Need to obtain clearance for informed consent first. If an interpreter is needed for this, make accommodations for one (culturally sensitive)

111
Q

Thyroid Stimulating Hormone TSH Levels:

A

0.5-5.0 Mu/L

112
Q

Steps in checking thyroid levels include?

A

First we check TSH to see if it is abnormal BEFORE checking t3 and t4

113
Q

Symptoms of hypothyroidism can mimic __________
Symptoms of hyperthyroidism can mimic __________

A

Depression for hypothyroidism

mania for hyperthyroidism

114
Q

-HYPERTHYROIDISM- TSH is
symptoms are:

A

TSH is low, T3/T4 are high
-Agitation, anxiety, heat intolerance, irritability, tachycardia, mood swings, weight loss.

115
Q

HYPOTHYROIDISM- TSH is
Symptoms are:

A

HIGH T3/T4 are low
-Cold intolerance, lethargy, weight gain, decreased libido

116
Q

T3 and T4 relationship with TSH

A

T3 and T4 have an inverse relationship with TSH. So when one is up, the other is down.

117
Q

Pts TSH level is 0.04 and has ______
t3 and t4 indicative of

A

high, hyperthyroidism

118
Q

Pt comes in with low t3 and t4 with a TSH of 0.07

A

hypothyroidsim

119
Q

What intrauterine adverse rx can depakote create?

A

Spina Bifida

120
Q

What organ can depakote injure the most? Black box warning?

A

Hepatotoxicity

121
Q

signs of hepatotoxicity

A

abdominal pain in RUQ, reddish brown urine, yellowing of the skin, whites of the eyes and fatigue

122
Q

Pt taking Depakote presents with signs of hepatotoxicity 🡪 abdominal pain in the upper right portion of the abdomen, reddish brown urine, yellowing of the skin and whites of the eyes and fatigue.

A

Discontinue the medication first
-Check liver function tests second. AST (5-40) ALT (5-35)

123
Q

Normal values of AST and ALT

A

(5-40) ALT (5-35)

124
Q

Therapeutic range for valproic acid is

A

50-125

125
Q

TOXIC level for valproic acid and signs and symptoms

A

greater than 150
disorientation, lethargy, resp depression, nausea and vomiting

126
Q

What do you do if a patient comes in with s/s of valproic acid?

A

Interventions: Discontinue med, check valproic acid levels, LFT and ammonia levels (15-45)
Ammonia level rises causes disorientation

127
Q

Kava Kava: is used for

A

anxiety, stress and insomnia.

128
Q

Kava can cause what adverse reaction? what is the priority lab?

A

CAN CAUSE LIVER DAMAGE
LFT labs

129
Q

What medications do patients want to avoid mixing Kava with

A

Sedatives or benzos
because it can cause drowsiness

130
Q

Lamictal can cause what adverse rx?

A

Steven Johnsons syndrome

131
Q

S/s of steven johnson’s syndrome??

A

Severe rash- Fever, body aches, red rashes, peeling skin, facial and tongue swelling.

132
Q

If patient starts lamictal and has a sudden onset of fever what is the next step?

A

DC medication

133
Q

What is the mood stabilizer that causes the LEAST amount of weight gain? and least amount of risk for metabolic syndrome

A

Lamictal

134
Q

What antipsychotics cause the least amount of weight gain? (3)

A

Geodon, Aripiprazole, Lurasidone (latuda)

135
Q

For patients taking antipsychotics that cause weight gain, check routine labs such as (4)

A

BMI, Hip to waist ratio, glucose and lipid panel. These patients have an increased chance of metabolic syndrome

136
Q

Management of Antipsychotic induced weight gain (AIWG) pharmacological and non pharmacological txs?

A

Exercise and nutritional counseling are nonpharmacologic strategies
Pharmacologic interventions consist of switching to another antipsychotic that has a less potential to cause weight gain such as a ZAL.

137
Q

pt is taking quetiapine (Seroquel) , paliperidone (Invega) or risperidone (Risperdal) but its causing them to gain weight and they aren’t exercising, your INITIAL action as a PMHNP

A

to encourage exercise and nutritional counseling FIRST.
🡪 if this doesn’t work, THEN you can talk about switching their med to a ZAL

138
Q

Carbamazepine (Tegretol) - Black Box warning

A

Agranulocytosis (decreased WBC)
(Agranulocytosis, Asians, Aplastic anemia)

139
Q

Agranulocytosis (decreased WBC) S/S

A

aplastic anemia (pallor, fatigue, headaches,fever, nosebleeds, bleeding gums, skin rash, shortness of breath)

DC MED

140
Q

Tegretol and Asians

A

Steven johnsons Syndrome, particularly in ASIANS 🡪 screen for HLAB 1502 allele BEFORE initiating Tegretol

If the question asks what needs to be done before initiating Tegretol and specifying Asians, answer is HLAB 1502 Allele.–> this is highly associated with the outcome of carbamazepine induced steven johnsons.

141
Q

Agranulocytosis can be caused by Carbamazepine and Clozaril.
Monitor patients taking this for signs and symptoms

A

infections (sudden fever, chill\s, sore throat, weakness)

142
Q

When do you dc Carbamazepine/ Clozaril r/t ANC

A

is less than 1000mm, even If the patient is NOT showing signs of infection. DC med and recheck lab.

143
Q

Lithium levels? and toxicity level

A

Lithium 0.6-1.2 eq/L
Lithium toxicity can occur when this level reaches 1.5 or higher.

144
Q

If lithium level is 1.3 or 1.4 what do you do? ( no signs of toxicity)

A

Keep monitoring patient for toxicity

once 1.5 IMMEDIATELY discontinue
-If the level is 1.3 or 1.4 and showing signs of toxicity, DISCONTINUE.

145
Q

Neuroprotective treatment of choice for bipolar

A

is lithium. This can protect nerve cells from damage.
-GOLD STANDARD FOR TREATING MANIC EPISODES

146
Q

if pt is suicidal what is the medication with evidence of antisuicidal effect

A

-If pt is suicidal= lithium. *Evidence of antisuicidal effect.

147
Q

only known antipsychotic that has been shown to reduce the risk of suicide in patients with schizophrenia-

A

Clozaril, watch for agranulocytosis

148
Q

Labs before Lithium

A

TSH, thyroid panel, Kidney function tests, a risk for kidney disease and a greater risk for lithium toxicity.

149
Q

Normal creatinine and BUN monitor for lithium

A

0.6-1.2 and BUN 10-20.

150
Q

Urinalysis for lithium

A

check for proteins in urine, a large amount of protein 4+ 🡪 may indicate kidney disease. Do not stop lithium, just monitor closely for toxicity.

151
Q

females of childbearing age 12-51 years old what is a priority lab.

A

-HCG-
Choose hcg if pt is of child bearing age. Can cause neural tube defect

152
Q

Side effects of lithium:

A

-Hypothyroid- tiredness, weight gain, dry skin, constipation, coarse hair, puffy face
-Fine hand tremors, MACULOPAPULAR RASH, GI upset (diarrhea, vomiting, cramps, anorexia, polyuria, polydipsia, diabetes insipidus, T WAVE inversions and LEUKOCYTOSIS

153
Q

lithium can cause what to ECG?

A

T WAVE inversions

154
Q

Ebstein Anomaly (congenital heart defect) can be caused by what medication?

A

lithium

155
Q

Lithium toxicity s/s (9)

A

Severe nausea, vom, diarrhea, confusion, drowsiness, muscle weakness, palpitations, coarse hand tremors , UNSTEADINESS WHILE STANDING OR WALKING- ATAXIA

DC MED and check lithium levels first

156
Q

What medications can effect lithium levels in body? (4)

A

drugs that have renal clearance
therefore increasing lithium levels
NSAIDS, Thiazide, ACE inhibitors, lisinopril.

157
Q

What sodium levels can increase lithium levels?

A

hyponatremia:
The kidneys treat lithium and sodium similarly which is the reason sodium depletion can significantly elevate lithium reabsorption

158
Q

Neuroleptic malignant syndrome is caused by what class of drugs

A

antipsychotics

159
Q

NMS s/s (6)

A

-extreme muscle rigidity
-Mutism
*hyperthermia
*tachycardia
*diaphoresis
*altered level of consciousness

LIFE THREATENING

160
Q

What labs need to be checked with NMS: (4)

A

-Elevated CPK (creatinine phosphokinase) caused by muscle contraction and destruction
-Myoglobinuria (from the breakdown of muscle cells 🡪rhabdo)
-Elevated WBC
-Elevated LFT

161
Q

what medication can be given for NMS for dopamine agonist?

A

Bromocriptine

Bromocriptine is given to reverse the hypodopaminergic state

162
Q

what medication can be given for NMS for muscle relaxant

A

Dantrolene

Due to a risk of hepatoxicity, dantrolene is typically discontinued once symptoms begin to resolve.

163
Q

how does a dopamine agonist work

A

A dopamine agonist is a type of medication that mimics the effects of dopamine by activating dopamine receptors in the brain, essentially “tricking” the brain into thinking it is receiving dopamine, and is primarily used to treat conditions where dopamine levels are low

164
Q

how do antipsychotics work on dopamine?

A

most antipsychotic medications act as dopamine antagonists. They block the activity of dopamine receptors in the brain, reducing the excessive dopamine signaling that is believed to contribute to psychotic symptoms such as hallucinations and delusions.

165
Q

serotonin syndrome caused by and 2 s/s

A

antidepressants
hyperreflexia and myoclonic jerks

166
Q

tx for serotonin syndrome

A

DC offending agent and give Cyproheptadine- antihistamine/anticholinergic

Cyproheptadine is an H1 blocking antihistamine, but it also has serotonin receptor blocking activity. Specifically, it acts to block 5-HT1A and 5-HT2A receptors, which are the receptors responsible for the symptoms of serotonin syndrome. The typical dose of cyproheptadine for serotonin syndrome is 12 mg

167
Q

what group of meds can cause serotonin syndrome?

A

SSRI/ SNRI/ TCA/ MAO and ST John’s Wort
Patients should not be on more than one class of these meds

168
Q

When switching from SSRI to MAOI you wait

A

14 days for the SSRI to DEGENERATE (clear out of the body)

169
Q

When switching from MAOI/TCA/SSRI/SNRI to PROZAC you wait

A

14 days

170
Q

when switching from Prozac (fluoxetine) to an MAOI/TCA/SSRI/SNRI wait

A

wait FIVE TO SIX WEEKS because of prozacs long half life.

171
Q

what migraine medications can cause serotonin syndrome?

A

Triptans (sumatriptan, Imitrex)

172
Q

If patient comes in and is taking a triptan, DO NOT give

A

SSRI/SNRI/MAOI/TCA because it will INCREASE the chance of serotonin syndrome

173
Q

If patient is on a triptan what type of medication can be prescribed

A

NDRI (Wellbutrin) or contact PCP to change their migraine medication

173
Q

If a patient is depressed and has cancer, Give ?

A

SSRI such as citalopram or Lexapro because they have fewer drug to drug interactions.

174
Q

a patient comes in and says they don’t want a drug that messes with their sexual function🡪 you can give

A

NDRI such as wellbutrin. This helps w depression and doesn’t cause sexual dysfunction.

175
Q

If a patient comes in with low energy and fatigue what else can you give them?

A

Wellbutrin it’s increases energy levels

176
Q

Contraindication of Wellbutrin?

A

hx of seizures because it lowers the seizure threshold. History of eating disorders.

177
Q

if patient has chronic neuropathy and is deprthe essed best type of medication to prescribe is?

A

SNRI
SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) are effective for treating neuropathy because they increase the levels of serotonin and norepinephrine in the brain, which are neurotransmitters involved in pain modulation,

178
Q

protocol for tx neuropathic pain

A

first: SNRI (safer)
TCA,
Alpha 2 delta ligand (pregabalin and gabapentin).

Choose SNRI over TCA bc of less adverse reactions

179
Q

16 year old on Prozac or paxil what do you want to do frequently

A

Assess thoughts of self harm frequency and severity everytime they come to their appointment.

180
Q

If a patient is depressed🡪 assess for

A

alcohol intake because etoh can exacerbate depressive symptoms which act as a barrier to treatment.

181
Q

Prozac can cause insomnia what do you then recommend

A

take it in morning before prescribing new medication

182
Q

antisocial personality disorder has an increase in what type of ideation

A

homicidal

183
Q

increased dopamine in the MESOLIMBIC pathway “reward pathway”- dopaminergic is responsible for

A

positive symptoms of schizophrenia

184
Q

mesolimbic pathway connects:

A

connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain.

Yes, the mesolimbic pathway connects the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens, making it essentially a “reward pathway” in the brain responsible for motivation and pleasure-related behaviors

185
Q

positive symptoms in schizophrenia are, and tx is

(8)

A
  • Symptoms can be controlled w antipsychotics (they respond positively)
    -Hallucinations, delusions, referential thinking, disorganized behavior, hostility, grandiosity, mania and suspiciousness.
186
Q

negative symptoms in schizophrenia are (7) and tx

A

Flattened affect, alogia or poverty of speech, apathy, abstract thinking problems, anhedonia and attention deficits.

atypical antipsychotics

187
Q

decreased dopamine in the MESOCORTICAL pathway- connects the ventral tegmentum to the prefrontal cortex

A

negative symptoms of schizophrenia

188
Q

schizophrenia age of onsets for males and females

A

Age of onset- 18-25 males
25-35 females

189
Q

MRI or PET scan to visualize the brain structures of schizophrenic patients what are the findings

A

everything decreasing in size except the ventricles

-Abnormalities or changes/ deficits in the prefrontal cortex, amygdala, basal ganglia, hippocampus and limbic regions of the brain can cause aggression, impulsivity and abstract thinking issues

190
Q

stimulants and schizophrenia

A

AVOID stimulants bc they can increase dopamine and make positive s&s worse

191
Q

what dx has low tolerance to guanfacine and clonidine.

A

schizophrenia

192
Q

ACT TEAM

A

Non pharmacologic tx for schizophrenia
- For patients with severe mental illness in the community when they are discharged
- Case management approach
Ex: if patient has long term history (keyword) of noncompliance with meds, the act team will go to their homes and administer the meds
-this is a 24/7 service

193
Q

Primary prevention-

A

aimed to decrease the incidence of new cases- helps people avoid stressors/ cope easier

194
Q

stress management, smoking PREVENTION classes, DARE, vaccinations are what levels of prevention

A

primary

195
Q

b) Secondary prevention

A

aimed at decreasing the prevalence # of already existing cases🡪 early case findings, SCREENINGS and prompt and effective treatment

196
Q

phone hotline, crisis intervention, disaster response, SCREENINGS are examples of what level of prevention

A

secondary

197
Q

c) Tertiary prevention

A

aimed to decrease the disability and severity of a mental disorder🡪 rehab services, avoidance or postponement of complications

198
Q

day treatment programs, case management for physical, housing or vocational needs, SOCIAL SKILLS TRAINING are examples of what levels of prevention

A

tertiary

199
Q

pt with schizophrenia might need you to refer them to an exercise program, specially AEROBIC to improve cognition, quality of life and overall long term health

example of what level of prevention

A

tertiary

200
Q

Say a patient is currently taking Haldol and is at high risk of relapse
Haldol 5MG BID
This pt has been hospitalized frequently, has had many ineffective antipsychotics and many med trials.
what is the next intervention?

A

Switch them from ORAL to IM (CLOSE MONITORING NEEDED)

201
Q

how to calculate haldol switch from PO to IM?

A

20X DAILY DOSE for monthly injection
10mg daily x20 = 200mg
100mg is the max dose at one time so you give 100mg and have them come back in 5-7 days and give the second dose of 100mg

202
Q

When doing a MSE on a preschooler 3-5 years old tips (2)

A

Listen and observe cues
-HEAVILY dependent on CLINICAL OBSERVATION

203
Q

pt thinks church members and family members are in a cult🡪 delusion disorder

ex: pt thinks they are out to get them

which one is delusion based vs paranoia based

A

Delusion: ex: pt thinks church members and family members are in a cult🡪 delusion disorder
Paranoid: ex: pt thinks they are out to get them

204
Q

tangential means

A

thought to thought with no point.

205
Q

-Circumstantial thought process

A

talks in circles providing unnecessary detail BEFORE getting to the point

206
Q

Themes that occupy thoughts and perceptual disturbances

A

Thought content

207
Q

Suicidal ideations/ homicidal ideations/plan, visual hallucinations, auditory hallucinations are all part of what part in MSE

A

thought CONTENT

208
Q

FOLSTEIN SCALE AKA as

A

mini mental exam

209
Q

FOLSTEIN SCALE is used for

A

assess cognition/quantify the cognitive status in ADULTS

210
Q

concentration/attention/calculation
orientation
registration
recall
fund of knowledge
clock drawing test

all are parts of the

A

MMSE

211
Q

I would like you to count backwards from 100 by sevens, or do serial sevens, months backwards is an example of what part of the MMSE

A

concentration, attention, calculation

212
Q

what’s the year? Season? Date? Where are we? are parts of what segment of the MMSE

A

orientation

213
Q

say the name of 3 unrelated objects clearly and slowly, allowing ONE second for each. After you said them, ask patient to repeat them is an example of what part of the MMSE

A

registration

214
Q

Wait five minutes, and ask pt if they can repeat the words in registration is what part of the MMSE

A

recall

215
Q

who is the president? is what part of the MMSE

A

fund of knowledge

216
Q

Clock drawing test (CDT) : used for

A

Used to screen for signs of neuro problems, such as Alzheimer’s or dementia.
-Very quick and only requires a minute or two
-If they are unable to draw, it can be caused by damage to the right parietal lobe, right hemisphere.

(Draw the clock to the right-right hemisphere)

217
Q

inability to build, assemble or draw objects
can be caused by lesions in the parietal lobe following strokes or can indicate Alzheimer’s
is called

A

Constructional Apraxia

218
Q

how do a typical and typical antipsychotics differ ?

A

Both atypical and typical antipsychotics have a dopamine antagonism, but ATYPICAL antipsychotics have an addition of serotonin receptor antagonism

219
Q

are atypicals or typical antipsychotics less likely to cause EPS and why

A

Atypical because of of the serotonin antagonism

220
Q

what makes atypical antipsychotics atypical?

A

Serotonin receptor antagonism 5HT2A

221
Q

If patient comes in with 1st psychotic episode caused by mental illness- what do you want to start them on

A

atypical

222
Q

when a pt is psychotic, they are at an increased risk of being dangerous to themself or others so you want to give med by

A

IM (Stabilizes quicker)

223
Q

IM atypticals (3)

A

geodon, Abilify, invega

224
Q

mesolimbic- ________ dopamine = ________ symptoms

A

increases and positive

225
Q

mesocortical- _________ dopamine = _________ symptoms

A

decreases and negative

226
Q

nigrostriatal pathway- Mediates _________-& __________ dopamine levels 2/2 dopamine blockade- _________ acetylcholine

A

motor movements,
decreases
increases

227
Q

________ dopamine levels lead to an increase in __________ Causing a ___________ in salivation (sialorrhea), teary eyes (Epiphora), diarrhea.

A

decreased
ACH
increase

228
Q

what happens to dopamine that causes the 5 types of EPS

A

blockade in dopamine

229
Q

painful neck, stiff neck, muscle spasms of neck muscles is what type of EPS

A

acute dystonia

230
Q

shuffling gait, motor slowing, mask facial expressions, pill rolling, tremors and muscle rigidity is what type of EPS

A

pseudo parkinson’s

231
Q

motor restlessness, inability to sit still, rocking, pacing or constant motion of unilateral limb “jump out of my skin”
is what type of EPS

A

Akathisia

232
Q

absence of movement, difficulty initiating motion, subjective feeling of lack of motivation to move is what type of EPS

A

Akinesia

233
Q

involuntary abnormal movement of muscles of the mouth, tongue, face, and jaw that can progress to limbs. This is from a long time of decreased dopamine and increased acetylcholine is what type of EPS

A

Tardive Dyskinesia

234
Q

what other medication can cause TD?

A

reglan

235
Q

tx for all EPS except TD is

A

cogentin

236
Q

what medication can worsen TD

A

cogentin

237
Q

TX for TD?

A

For TD you want to reduce the dose of the typical antipsychotic OR switch to an ATYPICAL antipsychotic

238
Q

prolactin increase, amenorrhea and galactorrhea (nipple discharge) occurs in what pathway and how

A

Tuberoinfundibular Pathway – decrease of dopamine because of the D2 blockage

239
Q

When a pt is on risperidone this is extremely important to look

A

for prolactin levels, sexual dysfunction, gynecomastia and osteoporosis
in men less than 20 and women less than 25

240
Q

-Clozapine is metabolized majorly by the

A

P450 enzyme CYP1A2

241
Q

Enzyme Inducers- ________ the metabolic activity of the drug thus

A

increases
DECREASES the drug level so you want to INCREASE the drug

242
Q

tobacco and oral contraceptives are examples of

A

enzyme INducers

243
Q

Patient is a non-smoker and on olanzapine they come back and tell you they started smoking. What do you do with the dose?

A

increase

244
Q

this patient comes back and says they stopped smoking, you would do what to the olanzapine

A

decrease

245
Q

Enzyme inhibitors- ______ the metabolism of the drug thus

A

inhibits
INCREASES the drug level so you want to DECREASE the drug

246
Q

can inducers or inhibitors cause toxic levels of drugs

A

inHIBITORS

247
Q

A patient comes in and is taking clarithromycin and erythromycin, you will do what to their drug dosage

A

decrease

248
Q

What if the patient is taking meds and is smoking and taking clarithromycin?

A

You will DECREASE the drug because the inhibitor takes preference, this is stronger and they take over the inducer.

249
Q

patient is on Tegretol and antibiotics- what would you do

A

you need to DECREASE Tegretol because the antibiotics will cause high levels

250
Q

Medications that can cause mania (4)

A

steroids
antabuse (disulfiram)
Isoniazid (INH)
antidepressants for bipolar pt

251
Q

Medications that can cause depression (7)

A

-steroids
-beta blockers (metoprolol, atenolol etc)
-interferon
-ISOTRETINOIN (ACCUTANE)
-Retroviral drugs (tenofovir, abacavir)
-benzos
-progesterone

252
Q

patient being treated for mood disorder with Tegretol and they are also taking flonase or prednisone if they come back weeks later saying Tegretol is not effective you would

A
  • increase the dose of mood stabilizer because of the steroids.
    -This is because flonase and prednisone have steroids which can exacerbate mood symptoms
253
Q

A patient being treated for depression and is taking Lexapro and interferon and says Lexapro is not effective 4-6 weeks later you would

A

increase lexapro
This is because the interferon can be exacerbating the depressive symptoms

254
Q

A Pt being treated for psychosis with abilify but is also taking flonase-

A

increase abilify
-this is because the flonase can be exacerbating the psychosis

255
Q

If patient is taking a medication that exacerbated their mental illness, you need to

A

increase the psychotropics

256
Q

Neurotransmitters involved in addiction-

A

dopamine and gaba gamma amino butyric acid

257
Q

Patient with anorexia comes in and complains of pain after eating, bloating or stomach fullness

A

delayed gastric emptying

258
Q

Medications that can cause delayed gastric emptying (3)

A

Ranitidine (Zantac)
Famotidine (Pepcid)
Omeprazole (Prilosec)

259
Q

Antacids/PPi’s can

A

decrease the absorption of psychotropics

260
Q

After taking the antacid or PPI, how long to wait until taking psychotropics

A

2 hours

261
Q

SSRIs can cause what in older adults

A

anxiety

262
Q

Ziprasidone (Geodon) is a ______ that fan cause what on the EKG

A

antipsychotic and QT prolongation/interval

263
Q

Citalopram (celexa) can cause what on EKG (max doses)

A

prolonged QT interval
not recommended to tx more than 40mg a day for adults and 20mg for older adults

264
Q

Chlorpromazine (Thorazine) is a __________ that can cause

A

Typical antipsychotic photosensitivity

265
Q

Apoptosis

A

neuronal loss/ cell death

266
Q

GREATEST RISK FACTOR for bipolar d/o

A

family history

267
Q

how to differentiate mania from hypomania

A

mania is at least 1 week, hypomania is 4 days (if test says 2-3 days it is still bipolar dx)

268
Q
A