Depakote, liver, etc.

Question 1

Depakote and pregnancy

Answer 1

can cause spina bifida

Question 2

Depakote black box warning

Answer 2

liver toxicity
RUQ pain
reddish brown urine
yellowing of skin and eyes

Question 3

intervention for hepatotoxiticy

Answer 3

DC depakote and do liver function test

Question 4

AST levels and ALT

Answer 4

AST 5-40U/L
ALT 5-35 U/L

Question 5

What drug is very similar to depakote?

Answer 5

Valproic acid (Depakote is just another formulary of it)

Question 6

Valproic acid therapeutic range

Answer 6

50-125 ug/ml

Question 7

Toxicity for valproic acid is

Answer 7

above 150 ug/mL

Question 8

Signs of valproic acid toxicity (5)

Answer 8

disorientation, lethargy, respiratory depression, nausea/vomiting

Question 9

Intervention for Valproic acid toxicity

Answer 9

DC medication, check valproic acid levels, liver function test, and ammonia levels

Question 10

Depakote can cause

Answer 10

Pancreatitis

Question 11

S/S of pancreatitis (8)

Answer 11

upper abdominal pain, abdominal pain that radiates to your back, tenderness when touching the abdomen, fever, rapid pulse, nausea, vomiting oily stools

Question 12

Kava

Answer 12

piper methysticum is a herbal supplement used for anxiety, stress, insomnia, muscle tension

Question 13

side effect of Kava

Answer 13

can cause liver damage

Question 14

Alcohol and Kava

Answer 14

concurrent use can increased risk of liver toxicity and other adverse effects

Question 15

Kava and benzos

Answer 15

kava can affect metabolism of certain medications processed by the liver effecting toxicity can potentiate sedative effects and increase risk of drowsiness and impariement