Topic 6 Synaptic Transmission Flashcards

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1
Q

How does voltage gated Ca2+ channel open and what does Ca2+ do?

A

Action potential arrives at synaptic know depolarises it, voltage gated calcium channel open allowing Ca2+ diffuse in (by facilitated diffusion) into synaptic knob.

Higher influx of Ca2+ into synaptic knob causes vesicle containing Acetylcholine fuse with pre-synaptic membrane.

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2
Q

After AcetylCholine bind fuse with pre-synaptic membrane how is voltage gated Na+ open?

A

When AcetylCholine fuse with pre-synaptic membrane, AcetylCholine released into synaptic cleft by endocytosis.

Acetylcholine diffuses across synaptic cleft to post-synaptic membrane and binds to complementary (Cholingeric) receptors causes Na+ channels on post synaptic membrane to open.

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3
Q

How is action potential causes in Synaptic transmission?

A

When Na+ channels open on post synaptic membrane to open Na+ diffuses into post-synaptic neurone causing depolarisation.

If threshold reached an action potential formed.

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4
Q

How is impulse stopped in Synaptic Transmission?

A

Acetylcholine removed from synaptic cleft and degraded by Acetylcholine esterase to prevent continuous impulse.

Products transferred into pre-synaptic neurone and Na+ channels close allowing post-synaptic neurone to reach resting potential.

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5
Q

How can cholinergic Synapse be inhibited?

A

Cl- move into post-synaptic neurone and K+ move out causing membrane potential reach which causes hyper-polarisation so action potential unlikely.

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6
Q

What is summation?

A

Rapid build of neurotransmitters to help generate action potential.

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7
Q

What is temporal summation?

A

1 neurone releases lots of neurotransmitters repeatedly over short time period so threshold value exceed.

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8
Q

What is spatial summation?

A

Many neurone collectively combining neurotransmitters to exceed threshold value.

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9
Q

What does agonists drug do?

A

Mimic shape of neurotransmitters and cause action potential.

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10
Q

How does an antagonist drug work?

A

Bind to receptors but block it preventing action potential.

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