Haemoglobin Unloading And Loading… Flashcards
What is Haemoglobin function?
Haemoglobin function is a carrier of oxygen through blood to respiring tissue for AEROBIC RESPIRATION to produce ATP
What is the structure of Haemoglobin?
Haemoglobin is a globular protein consists of 2-Alpha helix chain and 2-Beta Pleated sheets so has all together 4 polypeptide chains
How much Molecules can bind to Haemoglobin?
4 so their is 4 oxygen binding site so each chain has a haem group (Fe2+) that oxygen binds to haem group
What does Low oxygen partial pressure do to haemoglobin and what is low oxygen partial pressure?
Low oxygen partial pressure=Low oxygen concentration so less oxygen bind to Haemoglobin so LESS OXYGEN bind to Haemoglobin so Low affinity as oxygen less likely to bind.
What does high Oxygen Partial pressure?
High oxygen partial pressure=High oxygen concentration so more oxygen able to bind to Haemoglobin so high affinity as oxygen more likely to bind
Why is the the pressure saturation(x axis vertical) and the oxygen partial pressure(y axis horizontal) a S-shaped curve?
Low Gradient at the start because low Partial pressure so low affinity
Gradient become steeps as upon binding of first oxygen molecule causes tiertary structure of haemoglobin to change making it easier for the 2nd3rd.. oxygen to bind to Haemoglobin
Line goes straight because decrease in binding site availability
In the Pressure Saturation and Oxygen Partial pressure what does a decrease binding site do?
Decrease Binding site make it harder for oxygen to bind leads to oxygen Saturation when ALL 4 OXYGEN MOLECULE BIND TO HAEMGLOOBIN
What is the Bohr Affect?
[Give the Steps]
1.The Carbon dioxide dissolves in the blood forming CARBONIC ACID which lowers the pH
2.which causes the change in tertiary structure of Haemoglobin so has LOWER AFFINITY FOR OXYGEN RESULTS IN MORE OXYGEN DISSOCIATES AT RESPIRING TISSUE to COMPENSATE for high rate of respiration so MORE ATP PRODUCED
What happens when you excerise ?
[BOHR AFFECT]
When you excercise the rate of respiration increases as you are using more oxygen so MORE CARBON DIOXIDE produced so more Carbon dioxide dissolves in the blood.
Where does the graph shift when you have High Affinity?
High Affinity=Shift to the left
What is the advantage of Bohr affect?
More ATP produced
