6 Organisms respond to changes in their internal and external environments (A-level only) Flashcards
What is and how is restring potential maintained?
Resting potential is the difference in electrical charge between outside and inside of neurone when an Impulse isn’t being conducted (-70mv)
Maintained by Sodium-Potassium Pump
What and why is needed for sodium potassium pump and how many ions are inside and outside neurone and why is there more of one ion outside the neurone?
ATP is needed for Sodium-potassium pump due to involving Active transport.
3Na+ outside neurone and 2K+ inside neurone.
K+ ions diffuse out due to it more permeable for K+ leaving then Na+ entering.
How is action potential formed? Name 1-2
[Hint 5 steps]
1)Impulse received from receptors causing Na+ channel to open so Na+ enter neurone causing depolarisation. If depolarisation reaches threshold causes voltage gated Na+ activated leading to higher influx causing action potential.
2)When action potential reached voltage gated Na+ channel close while Voltage gated K+ channels open so repolarisation occurs K+ leave neuron.
How is hyper polarisation caused and how does this causes resting potential?
When most of K+ leave neurone causes hyper-polarisation VOLTAGE GATED K+ CHANNEL CLOSE
Sodium-Potassium pump returns neurone back to its resting potential
What type of response is action potential?
All or nothing responses.
What the purpose of the type of response action potentials are and how is it caused?
Action potentials purpose is to same voltage is reached every time and is important maintaining rates if impulse.
This caused by action potential depolarises axons to same voltage by voltage gated Na+ channel
What is refractory period and what is the purpose?
[Hint its to do with action potential]
Refractory period is period in action potential when axon can’t be depolarised to intimate another action potential
1)Limits frequency of action potential
2)Ensures action potential travel in one direction
What transmission of action potential in Non-Myelinated neurone? What is bad about it?
When depolarisation occurs voltage gated Na+ channel open further down axon by the time depolarisation has spread part of NEURONE has already been polarised
Non-Myelinated depolarisation occurs along WHOLE LENGTH OF AXON/Lamallae
Transmission of action potential in myelinated neurone?
Advantages of this
Action potential ONLY occurs at Nodes on Ranvier, action potential “jumps from node to node’ quicker saltory conducted
Myelination provides insulation
Factors that affect speed of impulse
1)Myelination increases speed as salrtory conduction occurs
2)Axon diameter wider axon=Faster Impulse
3)Increased in temp=Increased in speed of impulse however only certain temp due to denture of protein
Give the 3 steps of Transmission of Cholingeric Synapse.
1)Action potential arrives at synaptic knob depolarise it, causing voltage gated Ca2+ to open allowing Ca2+ diffuse into synaptic knob, a higher influx of Ca2+ into synaptic knob causes vesicle containing acetylcholine fuse with pre-synaptic membrane
2)Acetylcholine released into synaptic cleft by endocytosis, acetylcholine bind to Cholingeric receptors causing voltage gated Na+ to open on post synaptic membrane
3)Na+ diffuse in causing depolarisation, if depolarisation reaches threshold potential action potential formed.
How is continuous impulse stopped in Transmission of Cholingeric Synapse?
Acetylcholine removed from synaptic cleft and degraded by Acetylcholine esterase to prevent continuous impulse
Products transfers into PRE-SYNAPTIC Neurone and Na+ channel close allowing post-synaptic neurone to reach resting potential
How can Cholingeric synapse can be inhibited ?
Cl- move into POST-SYNAPTIC neurone and K+ move out causing membrane potential reach causing hyperpolarisation so action potential unlikely
What is Summation ?
Rapid build up of neurotransmitter to help generate action potential.
Give the 2 types of Summation?
Temporal Summation: 1 Neurone release lots of neurotransmitters repeatedly over short period so threshold value exceeds
Spatial Summation: Many neuronetransmitters collecting combining neurotransmitters to exceed threshold potential
What is the first thing that happens in the sliding filament theory?
Action potential travels to muscle fibres and depolarises the SACROLEMMA by T-Tubules causing the release Ca2+ from SarcoPLASMIC Reticulum
In sliding theory filament what does the Ca2+ do and what does it cause?
Ca2+ bind to tropomyosin molecules causing them to expose myosin binding site on the actin filament causing Actin-Myosin(head) cross bridge formed upon Actin and Myosin binding together causing a POWER STROKE
In sliding filament Theory what does power stroke do?
Power Stroke causes a cross bridge rotate towards centre of sacromere
In Sliding Filament Theory what causes the Myosin head to detach And what does this cause?
ATP is hydrolysed by ATP hydralyse to detach the myosin head ALLOWING REATTACHMENT at further site causing the Sarcomere to shorted Causing Muscle contraction
In Sliding Filament Theory what happens when the impulse stops?
When the impulse stops Ca2+ is actively transported back into the Sarcoplasmic Reticulm this allows Tropomyosin to block the Actin Filament from binding to myosin so muscle contraction stops.
What the Acronym to remember in Muscle Contraction?
dArk=A bands
LiGHT=I bands
What is the Thin filament? (Binding pattern of skeletal Muscle)
I band= Thin= Actin
What is the middle of the I band and what is it ?
Middle of I band= Z line= zLINE is the sarcomere
What is A band?
A band is Actin and Myosin so it is thick and thin filaments