Tolerance + Elimination Flashcards
1
Q
Metabolic tolerance is caused by an _____________ metabolism causing the drug to be broken down ______________
A
Increased metabolism
Broken down faster
2
Q
Cellular tolerance is caused by __________ ___________. When there are decreased ____________ for that drug, making it less effective
A
Down regulation
Decreased receptors
3
Q
Primary route for elimination
A
Kidney
4
Q
What do epithelial cells absorb/ secrete
A
Cuboidal cells
5
Q
Three steps of kidney elimination
A
- Glomerular filtration
- Tubular secretion
- Tubular reabsorption
6
Q
Hepatic elimination is through…
A
Biliary secretion, through the ducts to the small intestine
7
Q
When can GI excretion occur
A
When the drug is not absorbed
8
Q
How do the lungs eliminate drugs
A
Exhelation
9
Q
What is a primary example of drug residue
A
Drugs excreted into the mammary glands into the milk
10
Q
7 drug elimination routes
A
- Sweat
- Salivary
- Kidney
- Hepatic
- GI
- Lungs
- Mammary
