Distribution: Protein Binding

Question 1

Three factors that can alter tissue perfusion and effect drug distribution

Answer 1

1. Disease
2. Drug
3. Temperature

Question 2

What protein is in the plasma

Answer 2

Albumin

Question 3

How to overcome a drug that is highly protein bound

Answer 3

Use more

Question 4

Drug distribution is greatly affected by protein ________________

Answer 4

Binding

Question 5

Large protein molecules (_______________) trap drug molecules in the blood

Answer 5

Albumin

Question 6

A bound drug is….

Answer 6

Unable to leave capillaries and unavailable for effect

Question 7

Unbound drugs are available for effect, and are “______________” making them able to leave the _______________

Answer 7

Free
Capillaries

Question 8

Some diseases can cause ______________ resulting in decreased protein binding of certain drugs

Answer 8

Hypoproteinemia

Question 9

Diseases that result in hypoproteinemia create a danger of possible ______________ by increasing the amount of free drug and drug action due to decreased ______________ ______________

Answer 9

Toxicity/ overdose
Protein binding

Question 10

In animals with certain diseases, it is important to do ____________ ____________ before administering drugs to avoid possible toxicity due to _______________

Answer 10

Blood work
Hypoproteinemia (albumin)