Systemic Absorption Flashcards
What is systemic absorption
The passage of a drug from the site of administration to fluid (systemic circulation)
What are six drug factors that affect systemic absorption
- Drug form
- Drug interaction
- Mechanism
- Molecule size
- Solubility
- pH and ionization
8 patient factors that affect patient systemic drug absorption
- Age
- Species
- Genetics
- Stress
- Blood flow/ vascularity
- Metabolic state
- Nutritive state
- GI motility
Two types of waves in peristalsis
Segmental and motile
What is bioavailability
The percentage of drug absorbed / reaches circulation
A drug that has 100% bioavailability is given a value of…
1
A drug with a bioavailability value that is less than one is only _____________ ____________
Partially absorbed
How can you ensure that a drug you give will have 100% bioavailability
Give it IV or Intraarterial
What is an important difference between trade name and generic drugs
They may have different bioavailability, but required to have less than a 5% difference
The pH of a drug or the environment the drug is administered into affects _____________ _______________
Systemic absorption
