Absorption of Parenteral Forms + Distribution

Question 1

What are four factors that can affect the systemic absorption of parenteral forms of drugs

Answer 1

1. Formulation
2. Tissue Perfusion
3. Temperature
4. Hydrophilic nature (absorbs faster)

Question 2

An intramuscular injection or SQ injection of an oil suspension will have a ______________ effect

Answer 2

Repository

Question 3

Capillaries are “one layer” meaning….

Answer 3

One cell thick

Question 4

Membrane ____________ effects the distribution of the drug in the vascular system into the different ___________ in the body

Answer 4

Permeability
Tissues

Question 5

Spaces between cells that make a capillary wall, through which drug molecules can penetrate

Answer 5

Fenestrations

Question 6

Hepatic fenestrations are ___________ than typical capillary fenestrations

Answer 6

Larger

Question 7

Two barriers that have limited membrane permeability for distribution

Answer 7

BBB (blood brain barrier) and Placenta

Question 8

In order for molecules to cross the BBB, they must be very _______________ and _______________

Answer 8

Very small and Lipophilic

Question 9

Redistribution

Answer 9

Drug traveling from an area of high perfusion to low perfusion

Question 10

Tissue ___________ effects drug distribution

Answer 10

Perfusion (more = more distribution)