More Systemic Absorption

Question 1

Hydrophilic drugs are usually ____________

Answer 1

Ionized

Question 2

Lipophilic drugs are usually ____________

Answer 2

Non ionized

Question 3

Non ionized drugs (usually lipophilic) are absorbed well into an ___________ environment

Answer 3

Acidic

Question 4

Ionized drugs (usually hydrophilic) are poorly absorbed in a basic environment _____________

Answer 4

Ionized

Question 5

Ion trapping is administering drugs that will change the fluid _____________ charges which will alter ____________

Answer 5

Compartments
Absorption

Question 6

Hepatic first pass

Answer 6

Drug is eliminated by the liver via the portal system the first time going through the liver

Question 7

The form of a drug can effect systemic absorption. The size of an oral drug’s molecules will determine the ______________

Answer 7

Speed (smaller = faster)

Question 8

GI ____________ and the presence of _____________ are two factors that can effect the systemic absorption of oral drugs

Answer 8

motility
food

Question 8

Some drugs are eliminated on hepatic first pass. These drugs can’t be administered _____________

Answer 8

Orally

Question 9

The formulation of an oral drug will affect systemic absorption. Liquid is ____________ than pills

Answer 9

Faster