Safety and Effectiveness

Question 1

Therapeutic index

Answer 1

A margin of safety defined by
LD50 / ED50 = TI

Question 2

The TI is a margin of safety. Greater or wider = _____________

Answer 2

Safer

Question 3

Therapeutic range is the….

Answer 3

Concentration in plasma

Question 4

In order for a drug to be effective, the concentration in the plasma must be in the ____________ ______________

Answer 4

Therapeutic range (must be maintained)

Question 5

What are 3 factors that influence a drug reaching the Therapeutic Range

Answer 5

1. Route of Administration
2. Drug Dose
3. Dosage Interval and Duration

Question 6

When selecting a Route of drug administration, there are factors about both the Drug and the Animal to consider.
What are 3 factors to consider about the Drug?

Answer 6

1. Is the route effective (desired results)
2. Is the Drug soluble in water?
3. Is the Drug stable in the environment
   administered into?

Question 7

When selecting a Route of drug administration, there are factors about both the Drug and the Animal to consider. What are 2 factors to consider about the Animal?

Answer 7

1. Vomiting
2. Exigency status….how fast do I need this to take effect?

Question 8

Parenteral

Answer 8

Excluding the Intestines

Question 9

What are 3 Parenteral Routes?(Excluding the intestines)

Answer 9

1. Injectable
2. Inhalation
3. Topical

Question 10

What does Enteral mean and what are 2 Enteral Routes?

Answer 10

Intestinal Tract
1. Oral
2. Enteral Tubes