Biotransformation

Question 1

What happens when water comes into contact with the drug

Answer 1

“Splits” the drug (hydrolysis)

Question 2

Conjugation

Answer 2

Conjoined with something else

Question 3

What are drugs usually conjugated to in biotransformation that CATS do not have

Answer 3

Glucuronyl Transferase

Question 4

Biotransformation is primarily in the LIVER. Name five other organs that can help biotransformation

Answer 4

1. Kidney
2. Small intestine
3. Brain
4. Lungs
5. Skin

Question 5

What is drug detoxification and where does it take place?

Answer 5

Altering the structure of the drug in the Liver

Question 6

What could eventually happen after induction (increased production) of cytochrome P450 enzyme

Answer 6

Tolerance

Question 7

Inhibition of Cytochrome P450 enzyme will alter metabolism, making the drug…

Answer 7

Ineffective

Question 8

Liver function will effect biotransformation. Liver function on blood work should….

Answer 8

Alter dose

Question 9

Tolerance is repeated ____________ resulting in a ___________ ____________ to the drug

Answer 9

Repeated dosing
Decreased tolerance

Question 10

Two forms of tolerance

Answer 10

Metabolic and Cellular