Thyroid drugs Flashcards
early sign of agranulocytosis
sore throat
what might carbimazole cause
agranulocytosis > neutropenia > sepsis
drug used in first trimester of pregnancy in hyperthyroidism
Propylthiouracil- PTU
dosage for ptu
twice daily
dosage for carbimazole
once daily
dosage for levothyroxin e
once daily before breakfast
first line drug in hyper
carbimazole
MOA of carbimazole
blocks TPO so block thyroid hormone synthesis so decreases production of t3/t4
does carbimazole affect the foetus
yes
first line drug in hypo
levothyroxine
when might dosage of levothyroxine increase
in pregnancy
when might you face adverse effects of levothyroxine
when the dosage is too high - signs of hyperthyroidism
what may affect the absorption of levothyroxine
iron tablets, calcium tablets, PPI’s