Adrenal gland disorders Flashcards
3 layers of adrenal gland
capsule
cortex
medulla
secondary disorders
problems with ACTH
tertiary disorders
hypothalamic
what does ACTH play a crucial role in
regulation of cortisol production by the adrenal glands
action of cortisol
- Catabolic hormone so increases blood sugar, lipolysis, proteolysis, supports blood pressure and cardiac output
- Affects mood
what can too much cortisol cause
euphoria and psychosis
what might cushings be due to
prolonged high dose steroid therapy e.g in asthma , ibd , ra
how to treat if you think adrenal insufficiency
treat immediately with steroids
how to treat if acutely unwell
urgent hydrocortisone
what is aldosterone regulated by
renin angiotensin system and plasma potassium
where is cortisol produced
adrenal glands specifically adrenal cortex
what is cortisol production regulated by
hypothalamic-pituitary-adrenal (HPA) axis:
Thehypothalamusreleasescorticotropin-releasing hormone (CRH).
This signals thepituitary glandto releaseadrenocorticotropic hormone (ACTH).
ACTH stimulates theadrenal cortexto produce and releasecortisolinto the bloodstream
what is aldosterone activated in response to
low blood presssur
MOA of corticosteroids
Bind intracellular receptors
Receptor/ligand complex binds DNA to affect transcription
classes of steroid receptor
Glucocorticoid
Mineralocorticoid
Progestin
Oestrogen
Androgen
Vitamin D
