Graves disease

Question 1

what is it

Answer 1

autoimmue condition i which the immune sytsem attacks thyroid gland

Question 2

what anitbody does the immune system produce in graves disease

Answer 2

thyroid stimulating immunoglobulin - TSI

Question 3

action of TSI

Answer 3

mimics the action of thyroid stimulating hormone which normally regulates thyroid hormone productio

causing the thyroid to become overactive and secrete excessive amounts of thyroid hormones

Question 4

risk factors for graves

Answer 4

family histroy
women
environmental factors
20s-50s

Question 5

investigations

Answer 5

low TSH
raised t3 and t4
hypercalcaemia
raised alp
low white cell count
TSH receptor antibody

Question 6

autoantibodies in graves

Answer 6

Anti TPO 70-80
anti thyroglobulin 30-50
tsh reeptor antibody- 70-100

Question 7

specific graves signs

Answer 7

pretibial myxoedema
thyroid bruit
thyroid acropachy

Question 8

what is thyroi bruit

Answer 8

bnormal sound that can be heard during a physical examination over the thyroid gland, typically when using a stethoscope. This sound is often described as a whooshing or swishing noise and is produced by turbulent blood flow in the arteries or veins that supply the thyroid gland.

Question 9

graves eye disease

Answer 9

20% of graves patients
assoc with smoing
can be unilateral
if mild treat with lubricants - topically
if severe- steroids