Thyroid And Antithyroid

Question 1

Inhibition of TRH or TSH without hypo or hyperthyroidism

Answer 1

Dopamine
Levodopa
Corticosteroids
Somatostatin
Metformin
Bexarotene

Question 2

Induction of TSH with hypo or hyper

Answer 2

Iodides
Lithium
Aminogluthetimide
Thioamides
Ethionamide

Question 3

Increase TBG

Answer 3

Estrogen
Tamoxifen
Heroin
Methadone
Mitotane
Fluorouracil

Question 4

Decrease TBG

Answer 4

Androgen

Glucocorticoids

Question 5

Displacement of t3 and t4 from tbg

Answer 5

Salicylates
Fenclofenac
Mefenamic acid
Furosemide

Question 6

MoA of thioamides

Answer 6

Inhibit thyroid peroxidase catalyzed reaction

Question 7

AE of methimazole

Answer 7

Altered sense of taste
Cholestatic jaundice
Agranulocytosis

Question 8

What is the MoA of iodides

Answer 8

Organification
Hormone release
Decease size and vascularity of the gland

Question 9

Clinical use of iodides

Answer 9

Thyroid storm

Pre operative thyroidectomy

Question 10

Clinical use of lugol’s solution

Answer 10

Neonatal grave’s disease

Question 11

Iodine toxicity

Answer 11

Brassy taste

Acneform lesions

Question 12

What do beta rays promote

Answer 12

Epithelial swelling and necrosis
Follicular disruption
Edema
Leukocyte infiltration

Question 13

Use of radioactve iodine

Answer 13

Graves disease

Treatment of relapse of hyperthyroidism

Question 14

AE of radioactive iodine

Answer 14

Hypothyroidism
Sore throat
Sialitis

Question 15

MoA of anion inhibitors

Answer 15

Block uptake of the iodide

Question 16

Used to control tachycardia, hypertension and atrial fibrillation

Answer 16

Beta blockers
Metoprolol
Atenolol
Esmolol

Question 17

Potent inhibitor of T4 to T3

Answer 17

Desethylamiodarone