Sympathetics Flashcards
Directly interact with and activate adrenoreceptors
Cathecolamine
Epinephrine
Norepinephrine
Displaces stored catecholamine
Tyramine
Inhibits reuptake of released catecholamine
Cocaine
Trycyclic antidepressant
What are the 3 components of the G protein mediated response
GPCR
G protein
Effector protein
Mixed type of alpha and beta agonist
Norepinephrine
Epinephrine
Alpha agonist that is more on A1
Phenylephrine
Methoxamine
Clonidine
Alpha agonist more on A2
Methynorepinephrine
Beta agonist that are more b1
Dobutamine
Beta agonist B1 = B2
Isoproterenol
Dopamine agonist D1 = D2
Dopamine
Dopamine agonist D1 more than D2
Fenoldopam
Vascular smooth muscle
Heart
Pupil
A1
Contraction
Dilates pupil
Increase force of contraction
Platelets and fat cells
A2
Aggregation
Inhibits lipolysis
B1
Heart
JG cells
Increase force and rate
Increase release of renin
B2
Respiratory
Uterine
Liver
SM relaxation
Glycogenolysis
B3
Bladder
Fat cells
Relaxes destrussor
Lipolysis
D1
Smooth muscle
Dilates renal blood vessel
Epinephrine
Activation of A1 B1 b2
Alpha receptor - vasoconstriction
B1 receptor - Cardiac stimulation
B2 receptor - Bronchodilation
Uses of terbutaline and ritodrine
Prevent premature labor
Terbutaline can be used for asthma
Usage for phenylephrine
Mydriatic
Increase BP
Decongestant
Clonidine and methyldopa effects
Decrease BP through actions in the CNS
Amphetamine variant
Used among children with ADHD
Methylphenidate
Usefullness in adhd
Modafinil
This is a NE uptake inhibitor
Used in adhd
Atoxmoxetine