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Pharma A > Bone Mineral Homeostasis > Flashcards

Bone Mineral Homeostasis Flashcards

1
Q

MoA of teriparatide

A

Stimulates bone turnover

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2
Q

Clinical use and AE of teriparatide

A

Osteoporosis

Hypercalcemia
Hypercalciuria

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3
Q

MoA of Calcitriol on

Intestine and bone

A

Intestine
Induction of new protein synthesis
Modulation of calcium flux

Bone
Induce rank ligand

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4
Q

Uses of calcitriol

A

Hypocalcemia

Secondary hyperPTH to CKD

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5
Q

AE of vitamin D

A

Hypercalcemia can lead to renal failure

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6
Q

Can decease plasma concentration of calcium

A

Digoxin

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7
Q

CI of Calcium

A

Hypercalciuria
Nephrolithiasis
Sarcoidosis
HyperPTH

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8
Q

What are the effects of Calcitonin

A 
Decrease renal absorption 
Calcium
Phosphate
Sodium Potassium
Magnesium
Inhibits osteoclastic
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9
Q

Potent stimulator of calcitonin

A

Pentagastrin

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10
Q

MoA of glucocorticoid

A

Stimulate renal calcium excretion
Block bone formation
Pth stimulated bone resorption

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11
Q

AE of glucocorticoid

A

Osteoporosis

Stunt skeletal development in children

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12
Q

What are the Bisphosphonates

A

Etidronate
Alendronate
Risedronate
Tiuudronate

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13
Q

MoA of Bisphosphonates

A

Inhibit recruitment and promote apoptosis of osteoclast

Indirect stimulate osteoblast activity

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14
Q

What can impair the absorption of biphosphonate

A

Foos

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15
Q

MoA of plicamycin

A

Interrupt dna directed rna synthesis

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16
Q

MoA of strontium renelate

A

Block osteoclast differentiation and apoptosis

17
Q

MoA of Cinacalcet

A

Blocks PTH secretion

18
Q

Given for emergency of hypercalcemia

A

Galium Nitrate

19
Q

Action of Phosphate

A

Reduce serum calcium

Pharma A (19 decks)

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