Adrenocortical

Question 1

MoA of aminoglutethimide

Answer 1

Blocks the conversion of cholesterol to pregenolone

Question 2

Aminoglutethimide is combined with what if the px has breast cancer

Answer 2

Dexamethasone of hydrocortisone

Tamoxifen

Question 3

AE of aminoutethimide

Answer 3

Lethargy

Skin Rash

Question 4

Non selective inhibitor of adrenal and gonadal steroid synthesis

Answer 4

Ketoconazole

Question 5

Clinical use of ketoconazole

Answer 5

Cushing’s syndrome

Inhibitor for hypercortisolism

Question 6

AE of ketoconazole

Answer 6

Hepatoxicity

Question 7

What is the primary use of etomidatw

Answer 7

General anesthesia and sedation

Question 8

Reduces synthesis of adrenal and gonadal steroids

Answer 8

Abiraterone

Question 9

Used for refractory prostate cancer

Answer 9

Abiraterone

Question 10

This drug stabilizes HSP and steroid receptor

Answer 10

Miferistone

Question 11

Reduces cortisol production

Answer 11

Metyrapone

Question 12

Excretion of spironolactone

Answer 12

Renal and bile

Question 13

Excretion of eplerenone

Answer 13

renal and gi

Question 14

More selective to aldosterone receptor

Answer 14

Eplerenone

Question 15

They can increase eplerenone concentrations

Answer 15

Itraconazole
Ribonavir
Calrithromycin