Neoplastic Drugs

Question 1

Nitrosurea drugs

Answer 1

Carmustin
Lomustine
Semustin

Question 2

what kind of neoplasm does the nitrosurea target

Answer 2

Brain tumor

Question 3

Drug used for insulin secreting islet cell carcinoma of the pancreas

Answer 3

Streptozocin

Question 4

What are the non classic alkylating agent

Answer 4

Procarbazine
Dacarbazine
Brndamustine

Question 5

This is an oral agent for HL, NHL, brain tumor and a methylhydrazine derative

Answer 5

Procarbazine

Question 6

MoA of PROCARBAZINE

Answer 6

Inhibits DNA, RNA and CHON biosynthesis

Question 7

Parental agent for melanoma, HL, soft tissue and neuroblastoma

Answer 7

Dacarbazine

Question 8

Drug for CLL, HL, NHL and MM breast CA

Answer 8

Bendamustine

Question 9

This drug inhibits mitotic checkpoints

Answer 9

Bendamustine

Question 10

MoA of platinum analogs

Answer 10

Forms interstrand and intrastand that binds to nuclear and cytoplasmic

Question 11

What is the cytoprotective agent of cisplastin

Answer 11

Amifostine

Question 12

What drug causes nephrotoxicity and what do you do to counter the effect

Answer 12

Cisplastin

Chloride diuresis and water

Question 13

This is used as a broad spectrum against solid tumor

Answer 13

Carboplatin

Question 14

This drug is for colorectal cancer and uses the folfox regime and what condition worsen the drug

Answer 14

Oxaliplatin

Question 15

What are the active metabolites of procarbazine

Answer 15

Azoprocarbazine

H2O2

Question 16

What are the antifolate

Answer 16

Methotrexate
Permetrexed
Pralatrexate

Question 17

This has a high affinity to DHFR

Answer 17

Methotrexate

Question 18

Drug given for gestational trophoblastic disease (h mole and choriocarcinoma) and uses the folfox regimen

Answer 18

Methotrexate

Question 19

This drug is indicated for refractory or relapse t cell lymphoma

Answer 19

Pralatrexate

Question 20

This drug inhibits thymidilate synthesis

Answer 20

5-fluroruracil

Capecitabine

Question 21

What drug is catabolized by DDP

And part of the folfox regimen

Answer 21

5-fluroruracil

Question 22

This is the first line against metastatic colorectal cancer

Answer 22

Capecitabine

Question 23

This drug is highly schedule dependent and given via iv for continuous infusion for 5-7days

And limited to hematologic malignancy

Answer 23

Cytarabine

Question 24

This is used for childhood ALL

And has cytotoxic metabolite MMPR

Answer 24

6 thiopurine

Question 25

Drug that has immunosuppresive effects and decrease cd 4 and cd 8

Answer 25

Fludarabine | Cladiribine

Question 26

Used for hairy cell leukemia

Answer 26

Cladiribine

Question 27

What adjuvant does paclitaxel use when being adminsteres

Answer 27

Ethanol | Cremophor

Question 28

DoC for diabetic and cannot use paclitaxel

Answer 28

Docetaxel

Question 29

Novel microtuble inhibitor in the M phase

Answer 29

Ixabepilone

Question 30

AE of paclitaxel

Answer 30

Peripheral sensory neuropathy

Question 31

These drugs inhibit topoisomerase 2 in the S and G2 phase

Answer 31

Etoposide | Teniposide

Question 32

These drugs inhibit topoisomerase 1

Answer 32

Topotecan | Irinotecan

Question 33

Camptothecin can cross the bbb

Answer 33

Topotecan

Question 34

Prodrug that is converted to SN38 metabolite

Answer 34

Irinotecan

Question 35

What are the anthracycline drugs

Answer 35

``` Doxorubicin Daunorubicin Idarubicin Epirubicin Mitoxantrone ```

Question 36

Given for choriocarcinoma, gestational trophoblastoc and h mole

Answer 36

Dactinomycin

Question 37

AE of mitoxantrone

Answer 37

Blue discoloration

Question 38

Same AE of mitomycin and busulfan

Answer 38

Interstitial pulmonary fibrosis

Question 39

Used for chronic phase CML

Answer 39

Imatinib | Nilotinib

Question 40

Potent inhibitor of bcr abl tyrosine kinase inhibitor not effective against T3151 and V299L

Answer 40

Bosutinib

Question 41

Enhances response to chemotherapy and radiotherapy

Answer 41

Cetuximab | Panitumumab

Question 42

Antitumor activity G1 and immunologic mediated

Answer 42

Cetuximab