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Pharma A > Neoplastic Drugs > Flashcards

Neoplastic Drugs Flashcards

1
Q

Nitrosurea drugs

A

Carmustin
Lomustine
Semustin

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2
Q

what kind of neoplasm does the nitrosurea target

A

Brain tumor

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3
Q

Drug used for insulin secreting islet cell carcinoma of the pancreas

A

Streptozocin

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4
Q

What are the non classic alkylating agent

A

Procarbazine
Dacarbazine
Brndamustine

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5
Q

This is an oral agent for HL, NHL, brain tumor and a methylhydrazine derative

A

Procarbazine

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6
Q

MoA of PROCARBAZINE

A

Inhibits DNA, RNA and CHON biosynthesis

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7
Q

Parental agent for melanoma, HL, soft tissue and neuroblastoma

A

Dacarbazine

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8
Q

Drug for CLL, HL, NHL and MM breast CA

A

Bendamustine

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9
Q

This drug inhibits mitotic checkpoints

A

Bendamustine

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10
Q

MoA of platinum analogs

A

Forms interstrand and intrastand that binds to nuclear and cytoplasmic

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11
Q

What is the cytoprotective agent of cisplastin

A

Amifostine

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12
Q

What drug causes nephrotoxicity and what do you do to counter the effect

A

Cisplastin

Chloride diuresis and water

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13
Q

This is used as a broad spectrum against solid tumor

A

Carboplatin

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14
Q

This drug is for colorectal cancer and uses the folfox regime and what condition worsen the drug

A

Oxaliplatin

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15
Q

What are the active metabolites of procarbazine

A

Azoprocarbazine

H2O2

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16
Q

What are the antifolate

A

Methotrexate
Permetrexed
Pralatrexate

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17
Q

This has a high affinity to DHFR

A

Methotrexate

18
Q

Drug given for gestational trophoblastic disease (h mole and choriocarcinoma) and uses the folfox regimen

A

Methotrexate

19
Q

This drug is indicated for refractory or relapse t cell lymphoma

A

Pralatrexate

20
Q

This drug inhibits thymidilate synthesis

A

5-fluroruracil

Capecitabine

21
Q

What drug is catabolized by DDP

And part of the folfox regimen

A

5-fluroruracil

22
Q

This is the first line against metastatic colorectal cancer

A

Capecitabine

23
Q

This drug is highly schedule dependent and given via iv for continuous infusion for 5-7days

And limited to hematologic malignancy

A

Cytarabine

24
Q

This is used for childhood ALL

And has cytotoxic metabolite MMPR

A

6 thiopurine

25
Q

Drug that has immunosuppresive effects and decrease cd 4 and cd 8

A

Fludarabine

Cladiribine

26
Q

Used for hairy cell leukemia

A

Cladiribine

27
Q

What adjuvant does paclitaxel use when being adminsteres

A

Ethanol

Cremophor

28
Q

DoC for diabetic and cannot use paclitaxel

A

Docetaxel

29
Q

Novel microtuble inhibitor in the M phase

A

Ixabepilone

30
Q

AE of paclitaxel

A

Peripheral sensory neuropathy

31
Q

These drugs inhibit topoisomerase 2 in the S and G2 phase

A

Etoposide

Teniposide

32
Q

These drugs inhibit topoisomerase 1

A

Topotecan

Irinotecan

33
Q

Camptothecin can cross the bbb

A

Topotecan

34
Q

Prodrug that is converted to SN38 metabolite

A

Irinotecan

35
Q

What are the anthracycline drugs

A 
Doxorubicin
Daunorubicin
Idarubicin
Epirubicin
Mitoxantrone
36
Q

Given for choriocarcinoma, gestational trophoblastoc and h mole

A

Dactinomycin

37
Q

AE of mitoxantrone

A

Blue discoloration

38
Q

Same AE of mitomycin and busulfan

A

Interstitial pulmonary fibrosis

39
Q

Used for chronic phase CML

A

Imatinib

Nilotinib

40
Q

Potent inhibitor of bcr abl tyrosine kinase inhibitor not effective against T3151 and V299L

A

Bosutinib

41
Q

Enhances response to chemotherapy and radiotherapy

A

Cetuximab

Panitumumab

42
Q

Antitumor activity G1 and immunologic mediated

A

Cetuximab

Pharma A (19 decks)

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