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Pharma A > Parasympathetic > Flashcards

Parasympathetic Flashcards

1
Q

Choline is brought to the presynaptic terminal by what kind of transporter

A

Choline Transporter (CHT)

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2
Q

CHT is inhibited by what agent

A

Hemicholinium

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3
Q

What catalyzes the acetylCoA and Choline

A

Choline Acetyltransferase CHAT

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4
Q

What inhibits acetylcholine to be store in the vesicle

A

Vesamicol

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5
Q

What inhibits acetylcholine to the synaptic cleft

A

Botulinum

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6
Q

What is the cathecolamine neurotransmitter precursor for adrenergic transmission

A

Tyrosine

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7
Q

How is tyrosine converted to dopamine

A

Tyrosine kinase

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8
Q

What inhibits tyrosine kinase

A

Metyrosine

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9
Q

What inhibits dopamine to be stored in the vesicle

A

Reserpine

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10
Q

How is dopamine converted to Norepi

A

Dopamine beta hydroxylase

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11
Q

What inhibits Norepi to be exocytosed

A

Guanithidine

Bretyllium

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12
Q

What inhibits the reuptake of NE back to the presynaptic cell

A

Cocaine

Amphetamines

Tricyclic antidepressants

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13
Q

Can cause direct transmitter release from noradrenergix endings in a non calcium dependent process and not via vesicular fusion and exocytosis

A

Tyramine

Amphetamines

Ephedrine

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14
Q

N1 or NM has what kind of response

A

Endplate depolarization

Skeletal muscle contraction

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15
Q

Types of choline esters

A

Acetylcholine

Meta choline

Carbachol

Betanechol

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16
Q

Which choline acts on both cholinoreceptors

A

Acetylcholine

17
Q

What choline esters that are non susceptible to acetylcholinesterase

A

Carbachol

Betanechol

18
Q

which choline water acts on muscarinic receptor

A

Betanechol

19
Q

What are example of cholinomimetix alkaloids that are tertiary amines

A

Pilocarpine

Nicotine

Lobeline

20
Q

Bonding of what type of agonist would lead to activation of IP3 and DAG

A

M1

M3

M5

21
Q

Parasympathetic effect on the eyes

A

Miosis

Accommodation

Opens outflow for aqueous humor

22
Q

Parasympathetic effect on the CVS

A

Decrease peripheral vascular resistance

Decrease in heart rate

23
Q

What do you give to counteract the pilocarpine ineffective of hypotension to hypertension

A

Atropine

24
Q

GIT and GUT are controlled by what muscarinic receptor

A

M2

M3

25
Q

It is a simple alcohol with quarternary ammonium group

Used in MG, ileus and arrhythmias

A

Edrophonium

26
Q

This is carbamic acid used in glaucoma

A

Physostigmine

27
Q

What are examples of carbamic acid esters of alcohol that are quarternary ammonium

A

Neostigmine

Pyridostigmine

28
Q

Organophosphate that are irreversible

A

Echotiopate

Sarin

Parathion

Malathion

29
Q

Effect of cholinesterase inhibitors on the CVS

A

Decrease heart rate

Decrease cardiac output

Decrease impulse conduction

30
Q

Edrophonium effect on modest dosage on the cvs

A

Modest bradycardia

Cadiac output reduction

Increase vascular resistance

31
Q

Post operative ileus and congenital mega colon

A

Neostigmine

Betanechol

32
Q

Postoperative and post partum urinary retention

A

Neostigmine

33
Q

Gerd

A

Betanechol

34
Q

Sjorgen syndrome

A

Pilocarpine

35
Q

Reversal of surgically induced neuromuscular blockade

A

Neostigmine

Edrophonium

36
Q

For alzehemier’s disease

A

Donepezil

Galantamine

Rivastigmine

37
Q

Protection agents chemical warfare

A

Pyridostigmine

Pharma A (19 decks)

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