Anticoagulants Flashcards
Promotes platelet adhesion and activation
Collagen
VWF
Vasoconstrictors
Thromboxane A2
ADP
Serotonin
Primary hemostatic disorder shows bleeding where
Skin
Gums
Endometrium
Fibrin clot formation such as F8 bleeds where
Muscles
Joints
Retroperitoneum
Leiden variant of factor 5 cannot be deactivated by what
Protein C
Heparin monitoring is done with condition
Renal compromise
Obese
Pregnant
Heparin toxicities
Bleeding Allergy Hair loss, alopecia Osteoporosis Mineralocorticoid deficiency HIT
When is HIT seen
After surgery
What is given if px has HIT
Direct thrombin inhibitor
This drug effectively inactivated factor 10a
Fondaparinux
It is a teratogenic and can cause intracranial hemorrhage
Warfarin
What are the first that gets depleted
Factor 7 and protein C
Half life of vitamin K factors
7 - 6 hrs
9 - 24 hrs
10- 40 hrs
2 - 60hrs
Saddle nose
Retarded growth
Defects of limbs, eyes and central nervous system
Fetal Warfarin Syndrome
This factors can potentiate warfarin
Liver disease
Hyperthyroidism
Drugs
Factors that lessen warfarin effects
Pregnancy
Hypothyroidism
Hereditary resistance
Drugs
Drugs that lessen warfarin
Vitamin K Rifampicin Carbamazepine Barbiturates Colestyramine
Clinical uses of rivarxoban and apixaban
Prevent embolic stroke in AF
Prevent VTE after hip or knee surgery
Treatment and prevention of recurrence of VTE
This drug also inhibits platelet activation
Used for percutaneous angioplasty
Bivalirudin
Oral direct thrombin effect
Dagibatran
Significantly inhibits platelet TXA2 synthesis
Aspirin
Given for MI primary prevent in high risk
Aspirib
Inhibits ADP induced platelet aggregation
Thienopyridines
Clopidogrel
Ticlopidine
Prasugrel
Drug interaction with omperazole
Clopidogrel
