Anticoagulants

Question 1

Promotes platelet adhesion and activation

Answer 1

Collagen

VWF

Question 2

Vasoconstrictors

Answer 2

Thromboxane A2
ADP
Serotonin

Question 3

Primary hemostatic disorder shows bleeding where

Answer 3

Skin
Gums
Endometrium

Question 4

Fibrin clot formation such as F8 bleeds where

Answer 4

Muscles
Joints
Retroperitoneum

Question 5

Leiden variant of factor 5 cannot be deactivated by what

Answer 5

Protein C

Question 6

Heparin monitoring is done with condition

Answer 6

Renal compromise
Obese
Pregnant

Question 7

Heparin toxicities

Answer 7

Bleeding
Allergy
Hair loss, alopecia
Osteoporosis 
Mineralocorticoid deficiency
HIT

Question 8

When is HIT seen

Answer 8

After surgery

Question 9

What is given if px has HIT

Answer 9

Direct thrombin inhibitor

Question 10

This drug effectively inactivated factor 10a

Answer 10

Fondaparinux

Question 11

It is a teratogenic and can cause intracranial hemorrhage

Answer 11

Warfarin

Question 12

What are the first that gets depleted

Answer 12

Factor 7 and protein C

Question 13

Half life of vitamin K factors

Answer 13

7 - 6 hrs
9 - 24 hrs
10- 40 hrs
2 - 60hrs

Question 14

Saddle nose
Retarded growth
Defects of limbs, eyes and central nervous system

Answer 14

Fetal Warfarin Syndrome

Question 15

This factors can potentiate warfarin

Answer 15

Liver disease
Hyperthyroidism
Drugs

Question 16

Factors that lessen warfarin effects

Answer 16

Pregnancy
Hypothyroidism
Hereditary resistance
Drugs

Question 17

Drugs that lessen warfarin

Answer 17

Vitamin K
Rifampicin
Carbamazepine
Barbiturates
Colestyramine

Question 18

Clinical uses of rivarxoban and apixaban

Answer 18

Prevent embolic stroke in AF
Prevent VTE after hip or knee surgery
Treatment and prevention of recurrence of VTE

Question 19

This drug also inhibits platelet activation

Used for percutaneous angioplasty

Answer 19

Bivalirudin

Question 20

Oral direct thrombin effect

Answer 20

Dagibatran

Question 21

Significantly inhibits platelet TXA2 synthesis

Answer 21

Aspirin

Question 22

Given for MI primary prevent in high risk

Answer 22

Aspirib

Question 23

Inhibits ADP induced platelet aggregation

Answer 23

Thienopyridines

Clopidogrel
Ticlopidine
Prasugrel

Question 24

Drug interaction with omperazole

Answer 24

Clopidogrel

Question 25

Inhibit the final pathway of platelet aggregation

Utilizes for acute coronary events

Answer 25

Glycoprotein 2b/3a

Abciximab
Eptifibatide
Tirofiban

Question 26

When does the vitamin K effect manifest

Answer 26

After 6 hours

Question 27

Mild hemophilia A and vWf D what is given

Answer 27

Desmopressin acetate

Question 28

Used for HIT

Answer 28

Argatroban

Question 29

Contraindicated for TIA or stroke

Answer 29

Prasugrel