Pharmacokinetics Flashcards
This does not require energy, not saturable and proportional concentration
Passive diffusion
No energy required but carrier required and saturable
Facultative diffusion
The fraction of drug that reaches the systemic circulation of action after administration by any route
Bioavailability
In cell membranes this is more lipid soluble
Unionized molecule
Route of administration of drugs are determined by
Physical characteristic
Speed of absorb or release
Drug distribution is dependent on
Blood flow Size of the organ Binding Apparent volume of distribution Lipid solubility
When is the is the permeability rate limited
Drug is ionic,polar or water soluble
When is the drug perfusion rate limited
Drug is highly lipophilic
What binds to most acidic drugs
Albumin
Which binds to alkaline drugs
Alpha 1 glycoprotein
Globulin
Formula for volume distribution
Amount of drug in the body over plasma drug concentration
Responsible for metabolism of the largest proportion of drugs
CYP 3A4
Which phase where conjugates are almost invariably inactive
Phase 2 metabolic reactions
What are the drugs that can increase the activity of certain cyp isoforms
Phenobarbital Rifampin Phenytoin Carbamazepine St. John's wort Chronic ethanol consumption
This is a potent inhibitor of CYP3A4
Grapefruit juice
