Hyperlipidemia Flashcards
MoA of Statin
Inhibit HMGCoA
Rate limiting enzyme in hepatic cholesterol synthesis
HMG-CoA
Primary clinical effects of statin
Reduce LDL and TAG
Increase HDL
What are the other beneficial effects of statin
Inhibit monocyte migration and adhesion to endothelium Monocyte proliferation Oxidation of LDL Immune and inflam Stabilize atherosclerotic plaque
What statin drugs are metabolized by the CYP3A4
Simvastatin
Atorvastatin
Lovastatin
How is pravastatin metabolized
Glucoronidation
This AE primarily occurs at high dose of statin
Rhabdomyolysis
What statin has a fewer effect on the muscle
Pravastatin
What can inhibit CYP2A9
Warfarin
This inhibits the OATP3 transporter
Gemfibrozil
Considered as a second line and adjunct treatment
Bile acid binding resins
MoA of bile acid resins
Up regulation of cholesterol 7 a hydrolase
Downside of bile resin
Can generate vldl and tag in px with type 3 dyslipoproteinemia
Therapeutic use of bile acid resin
Primary hyperlipidemia young
Pruritus
Children and pregnant
AE of BaR
Constipation
Bloating
Flatulence
No ADEK except colesevelam
Cholesterol inhibitor
Ezetimibe
MoA of ezetimibe
Inhibits NPC1L1
Absorption of both dietary and biliary cholesterol
Common AE of ezetimibe
Flatulence
What drug can increase ezetimibe concentration
Cyclosporin
What is the only drug can significantly reduce lpA
Niacin
Most effective agent that can increase HDL
Niacin
AE of niacin
Skin flushing, pruritis and sensation of warmth
What is given sensation of warmth in niacin
Aspirin
Ibuprofen
They act as a ligand to PPAR
Fibrates
Fenofibrate
Gemfibrozil
