Thrombosis Lecture

Question 1

When are anticoagulants indicated?

Answer 1

used in venous thromboembolism

Question 2

When are fibrinolytic drugs indicated?

Answer 2

used in acute arterial and venous thrombosis

Question 3

When are antiplatelet drugs indicated

Answer 3

used in arterial thrombosis

Question 4

Is the heart treated like a venous or arterial system?

Answer 4

Venous

Question 5

Does heparin bind to activated or precursor coagulants?

Answer 5

activated

Question 6

What is the antidote for heparin?

Answer 6

protamine sulfate

Question 7

Does heparin cross the placenta?

Answer 7

no

Question 8

When LMWH do need to be monitored what is used?

Answer 8

Heparin assay (anti Xa assay) not PTT, but normally doesnt need to be monitored

Question 9

Describe the protein binding of warfarin and the significance of this?

Answer 9

99% is bound to albumin so drugs that displace it can effect its potency

Question 10

How is warfarin therapy reversed?

Answer 10

Stop the drug
administer vit K
prothrombin complex cencentrate

Question 11

Can warfarin be used during pregnancy?

Answer 11

no its a teratogen

Question 12

Does Fondaparinux have an antidote?

Answer 12

NO

Question 13

What drugs enhance warfarin metabolism?

Answer 13

barbituates and rifampin

Question 14

What drugs inhibit warfarin metabolism?

Answer 14

metronidazole, amiodarone, disulfiram

Question 15

Are there antidotes for direct inhibitors of Xa and IIa?

Answer 15

NO

Question 16

What is normal tPA specific for?

Answer 16

only for fibrin bound plasminogen

Question 17

Why is lower dose of aspirin more effective than higher dose in antiplatelet effects?

Answer 17

Because at higher dose aspirin has increasing effects on endothelial cells which produce prostacyclins