Inflammation Drugs Class/Mechanism Flashcards by Michael Canfield | Brainscape

Q

Acetylsalicyclic acid (ASA, Aspirin)

A

Salicylate

acetyl salicylic acid irreversibly acetylates COX 1 and 2; metabolite salicylic acid reversibly inhibits COX 1 and 2

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Q

Diflunisal

A

salicylate

difluorphenyl derivative of salicylic acid, which reversibly inhibits COX 1 and 2

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Q

Acetaminophen (Tylenol)

A

Para-amino phenol

reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Indomethacin

A

Indole

Reversibly inhibits COX 1 and 2 (favors COX1)

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Q

Sulindac

A

Indole

Reversibly inhibits COX 1 and 2 (Favors COX 1)

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Q

Ibuprofen (Advil, motrin)

A

Proprionic acid derivative

Reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Flurbiprofen

A

Proprionic acid derivative

Reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Naproxen (Aleve)

A

Proprionic acid derivative

Reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Oxaprozin

A

Proprionic acid derivative

Reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Piroxicam

A

Enolic acid

Reversibly inhibits COX 1 and 2 (favors COX 1)

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Q

Ketorolac

A

Heteroaryl acetic acids

Reversibly inhibits COX 1 and 2 (favors COX1)

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Q

Celocoxib (Celebrex)

A

COX 2 Inhibitor

Selectively inhibits COX 2 (10x, too bulky for COX 1 site)

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Q

Etoricoxib

A

COX 2 inhibitor

selectively inhibits COX 2 (100x, too bulky for COX 1 site)

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