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Pharm Unit 2 MJC > Thombosis Drugs Class/Mechanism > Flashcards

Thombosis Drugs Class/Mechanism Flashcards

1
Q

Unfractionated heparin

A

Indirect Thrombin inhibitor

Bind antithrombin, potentiating formation of antithrombin coagulation factor complex (Xa and IIa)

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2
Q

Dalteparin

A

Indirect thrombin inhibitor

LMWH that inhibits thrombin less effectively than Xa

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3
Q

Enoxaparin

A

Indirect thrombin inhibitor

LMWH that inhibits thrombin less effectively than Xa

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4
Q

Tinzaparin

A

Indirect thrombin inhibitor

LMWH that inhibits thrombin less effectively than Xa

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5
Q

Fondaparinux

A

indirect thrombin inhibitor

Synthetic polysaccharide that binds active site of antithrombin; inhibits Xa

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6
Q

Warfarin

A

Vitamin K antagonist
Blocks vitamin K dependent gamma carboxylation of factors 2,7,9,10 and proteins C and S (does not effect already synthesized factors.)

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7
Q

Bivalirudin

A

Direct thrombin inhibitor

Inactivate fibrinogen bound and unbound thrombin

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8
Q

Argatroban

A

Direct thrombin inhibitor

Inactivate fibrinogen bound and unbound thrombin

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9
Q

Dabigatran

A

Direct thrombin inhibitor

Inactivate fibrinogen bound and unbound thrombin

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10
Q

Rivaroxaban

A

Direct Xa inhibitor

Reversibly bind active site of Xa

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11
Q

Apixaban

A

Direct Xa inhibitor

Reversibly bind active site of Xa

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12
Q

Alteplase

A

Fibrinolytic

Lyse already formed clots by activating circulating plasminogen

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13
Q

Reteplase

A

Fibrinolytic

Lyse already formed clots; more clot specific, less systemic activation

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14
Q

Tenecteplase

A

Fibrinolytic

Lyse already formed clots; more clot specific, less systemic activation

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15
Q

Aspirin

A

Antiplatelet

irreversibly inhibits platelets, preventing TXA2 formation

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16
Q

Dipyridamole

A

Antiplatelet

PDE inhibitor –> increases platelet cAMP

17
Q

Clopidogrel

A

Antiplatelet

Inhibits platelet ADP receptors

18
Q

Abciximab

A

Antiplatelet

Monoclonal antibody against GP IIb/IIIa

19
Q

Eptifibatide

A

Antiplatelet

Fibrinogen analog which competes with endogenous fibrinogen for IIb/IIIa

20
Q

Tirofiban

A

Antiplatelet

Fibrinogen analog which competes with endogenous fibrinogen and vWF for IIb/IIIa

Pharm Unit 2 MJC (25 decks)

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