ANS II

Question 1

Describe the selectivity of muscarinic and nicotinic agonists (in general terms)

Answer 1

Muscarinic agonists are not ver selective between M1-5, some nicotinic agonists show selectivity between N1 and N2

Question 2

What are the two major classes of cholinomimetic drugs?

Answer 2

Direct acting and indirect acting.

Question 3

What are the two sub classes of direct acting cholinomimetic drugs

Answer 3

Choline esters and non-ester alkaloids

Question 4

What effect does the addition of a beta methyl group have on acetylcholine?

Answer 4

reduces potency

Question 5

What effect does the substitution of a carbamic acid group have on acetylcholine?

Answer 5

resistance to hydrolysis

Question 6

What causes a reduction in peripheral resistance due to vasodilation when muscarinic agonists are given?

Answer 6

vasodilation is due to muscarinic receptor-induced NO (EDRF) production in endothelial cells causing relaxation of vascular smooth muscle.

Question 7

How can muscarinic agonists reduce intraocular pressure?

Answer 7

By causing contraction of the ciliary body (M3)

Question 8

How could you test to see if neostigmine dosage needed to be increased or decreased in myasthenia gravis?

Answer 8

Give a small dose of transiently acting edrophonium.

Question 9

What does SLUDGE stand for?

Answer 9

Salivation, lacrimation, urination, defecation, GI distress, Emesis