Arthritis and Gout Drugs Class/Mechanism

Question 1

Indomethacin

Answer 1

Non Selective NSAID

Eliminate pain; reduce inflammation (But does not slow disease progression)

Question 2

Naproxen

Answer 2

Non Selective NSAID

Eliminate pain; reduce inflammation (But does not slow disease progression)

Question 3

COX-2 inhibitors

Answer 3

Selective NSAID

Eliminate pain; reduce inflammation (But does not slow disease progression)

Question 4

Quinolones

Answer 4

DMARD (Antimalarial)

Reduces T-cell activation and chemotaxis

Question 5

Glucocorticoids

Answer 5

DMARD
1 inhibits PLA2 (Inhibiting release of arachidonic acid and, thus, formation of prostaglandins)
2 Inhibits cytokine production (which prevents indcution of COX 2)

Question 6

Sulfasalazine

Answer 6

DMARD (immunosuppressive)

likely inhibition of IL-1 and TNF alpha release

Question 7

Methotrexate

Answer 7

DMARD (Immunosuppressive)
1 Inhibition of AICAR transformylase and thymidylate synthase, with seconday effects on PMN chemotaxis
2 Causes adenosine accumulation, which inhibits inflammation

Question 8

Leflunomide

Answer 8

DMARD (Immunosuppressive) Prodrug

Inhibits dihydoorotate dehydrogenase (involved in UMP synth) , which inhibits T-lymphocyte response to stimuli

Question 9

Etanercept

Answer 9

Biological Response Modifier

Blocks binding of TNF to TNF receptor

Question 10

Infliximab

Answer 10

Biological Response Modifier

Blocks binding of TNF to TNF receptor

Question 11

Adalimumab

Answer 11

Biological Response Modifier

Blocks binding of TNF to TNF receptor

Question 12

Golimumab

Answer 12

Biological Response Modifier

Blocks binding of TNF to TNF receptor

Question 13

Certolizumab

Answer 13

Biological Response Modifier

Blocks binding of TNF to TNF receptor

Question 14

Anakinra

Answer 14

BRM

IL-1 receptor antagonist

Question 15

Tocilizumab

Answer 15

BRM

IL-6 receptor antagonist

Question 16

Rituximab

Answer 16

BRM

Anti CD20 mAb, reduces circulating B-cells

Question 17

Abatacept

Answer 17

BRM

Inhibits T-cell activation and induces T-cell apoptosis

Question 18

Colchicine

Answer 18

Prevents tubulin polymerization and leads to inhibition of leukocyte migration, phagocytosis, and release of cytokines

Question 19

Probenecid

Answer 19

Uricosuric Agent

Compete with urate at the anionic transport site of the renal tubule and inhibit urate reabsoption

Question 20

Allopurinol

Answer 20

1 Reduces uric acid synthesis by inhibiting xanthine oxidase (competitive) which creates alloxanthine
2 alloxanthine is a non-competitive inhibitor of xanthine oxidase

Question 21

Febuxostat

Answer 21

Non-purine, non competitive antagonist of xanthine oxidase

Question 22

Pegloticase

Answer 22

Recombinant stabilized uricase

converts uric acid to allantoin